On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories
Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unv...
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| Fformat: | Online |
| Iaith: | Saesneg |
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Frontiers Media SA
2021
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| Pynciau: | |
| Mynediad Ar-lein: | 29628 |
| Tagiau: |
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869524868248109056 |
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| author | Fernando A. Arosa |
| author_browse | Fernando A. Arosa |
| author_facet | Fernando A. Arosa |
| author_sort | Fernando A. Arosa |
| collection | Directory of Open Access Books |
| description | Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unveiling that NK-like CD8+ T cells have many, sometimes contrasting, functions. The limited knowledge of the biology of this type of CD8+ T cells and the role they play within peripheral tissues and organs under homeostatic conditions has hampered our understanding of disease and therefore the possible development of disease diagnostic tools and effective immunotherapies. In this Research Topic are presented a variety of topics and views, some of them overlooked for many years, on human NK-like CD8+ T cells, which may open new and novel avenues of research to further our understanding of these polyfunctional T cells. |
| format | Online |
| id | doab-20.500.12854ir-55215 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-552152024-03-31T13:08:18Z On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories Fernando A. Arosa R5-920 RC581-607 Open conformers Disease control Adaptive Innate receptors Successful aging Regulatory Suppressor Tissue repair Cytotoxic MHC class I thema EDItEUR::M Medicine and Nursing Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unveiling that NK-like CD8+ T cells have many, sometimes contrasting, functions. The limited knowledge of the biology of this type of CD8+ T cells and the role they play within peripheral tissues and organs under homeostatic conditions has hampered our understanding of disease and therefore the possible development of disease diagnostic tools and effective immunotherapies. In this Research Topic are presented a variety of topics and views, some of them overlooked for many years, on human NK-like CD8+ T cells, which may open new and novel avenues of research to further our understanding of these polyfunctional T cells. 2021-02-11T21:38:05Z 2021-02-11T21:38:05Z 2018-11-16 17:17:57 2018 book 29628 16648714 9782889453962 https://directory.doabooks.org/handle/20.500.12854/55215 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4775/on-the-origin-and-function-of-human-nk-like-cd8-t-cells-charting-new-territories Frontiers Media SA 10.3389/978-2-88945-396-2 10.3389/978-2-88945-396-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889453962 121 open access |
| spellingShingle | R5-920 RC581-607 Open conformers Disease control Adaptive Innate receptors Successful aging Regulatory Suppressor Tissue repair Cytotoxic MHC class I thema EDItEUR::M Medicine and Nursing Fernando A. Arosa On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories |
| title | On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories |
| title_full | On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories |
| title_fullStr | On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories |
| title_full_unstemmed | On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories |
| title_short | On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories |
| title_sort | on the origin and function of human nk like cd8 t cells charting new territories |
| topic | R5-920 RC581-607 Open conformers Disease control Adaptive Innate receptors Successful aging Regulatory Suppressor Tissue repair Cytotoxic MHC class I thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Open conformers Disease control Adaptive Innate receptors Successful aging Regulatory Suppressor Tissue repair Cytotoxic MHC class I thema EDItEUR::M Medicine and Nursing |
| url | 29628 |
| work_keys_str_mv | AT fernandoaarosa ontheoriginandfunctionofhumannklikecd8tcellschartingnewterritories |