Origin and spatiotemporal dynamics of the peroxisomal endomembrane system
The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state...
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Frontiers Media SA
2021
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| Online dostop: | 18715 |
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| author | Richard A. Rachubinski Vladimir I. Titorenko |
| author_browse | Richard A. Rachubinski Vladimir I. Titorenko |
| author_facet | Richard A. Rachubinski Vladimir I. Titorenko |
| author_sort | Richard A. Rachubinski |
| collection | Directory of Open Access Books |
| description | The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell. |
| format | Online |
| id | doab-20.500.12854ir-55431 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-554312024-03-31T22:45:09Z Origin and spatiotemporal dynamics of the peroxisomal endomembrane system Richard A. Rachubinski Vladimir I. Titorenko QP1-981 Q1-390 peroxisomal endomembrane system development Reactive Oxygen Species Aging peroxisome Lipid Metabolism Endoplasmic Reticulum peroxisome biogenesis thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology The peroxisome is an organelle with essential roles in lipid metabolism, maintenance of reactive oxygen species homeostasis, and anaplerotic replenishment of tricarboxylic acid cycle intermediates destined for mitochondria. Peroxisomes constitute a dynamic endomembrane system. The homeostatic state of this system is upheld via two pathways for assembling and maintaining the diverse peroxisomal compartments constituting it; the relative contribution of each pathway to preserving such system may vary in different organisms and under various physiological conditions. One pathway begins with the targeting of certain peroxisomal membrane proteins to an endoplasmic reticulum template and their exit from the template via pre-peroxisomal carriers; these carriers mature into metabolically active peroxisomes containing the entire complement of membrane and matrix proteins. Another pathway operates via growth and maturation of pre-existing peroxisomal precursors that do not originate from the endoplasmic reticulum; mature peroxisomes proliferate by undergoing fission. Recent studies have uncovered new roles for the peroxisomal endomembrane system in orchestrating important developmental decisions and defining organismal longevity. This Frontiers Special Topic Issue is focused on the advances in our understanding of how evolutionarily distant organisms coordinate the formation, maturation, proliferation, maintenance, inheritance and quality control of the peroxisomal endomembrane system and how peroxisomal endomembranes communicate with other cellular compartments to orchestrate complex biological processes and various developmental programs from inside the cell. 2021-02-11T21:54:20Z 2021-02-11T21:54:20Z 2016-03-10 08:14:32 2015 book 18715 16648714 9782889194643 https://directory.doabooks.org/handle/20.500.12854/55431 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Origin_and_spatiotemporal_dynamics_of_the_peroxisomal_endomembrane_system/459#nogo http://journal.frontiersin.org/researchtopic/1057/origin-and-spatiotemporal-dynamics-of-the-peroxisomal-endomembrane-system Frontiers Media SA 10.3389/978-2-88919-464-3 10.3389/978-2-88919-464-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194643 148 open access |
| spellingShingle | QP1-981 Q1-390 peroxisomal endomembrane system development Reactive Oxygen Species Aging peroxisome Lipid Metabolism Endoplasmic Reticulum peroxisome biogenesis thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Richard A. Rachubinski Vladimir I. Titorenko Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| title | Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| title_full | Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| title_fullStr | Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| title_full_unstemmed | Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| title_short | Origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| title_sort | origin and spatiotemporal dynamics of the peroxisomal endomembrane system |
| topic | QP1-981 Q1-390 peroxisomal endomembrane system development Reactive Oxygen Species Aging peroxisome Lipid Metabolism Endoplasmic Reticulum peroxisome biogenesis thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 peroxisomal endomembrane system development Reactive Oxygen Species Aging peroxisome Lipid Metabolism Endoplasmic Reticulum peroxisome biogenesis thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18715 |
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