The Origin of the Plasma Cell Heterogeneity
Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controver...
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| Formatua: | Online |
| Hizkuntza: | ingelesa |
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Frontiers Media SA
2021
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| Sarrera elektronikoa: | 18857 |
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| author | Thierry Defrance Catherine Pellat-Deceunynck |
| author_browse | Catherine Pellat-Deceunynck Thierry Defrance |
| author_facet | Thierry Defrance Catherine Pellat-Deceunynck |
| author_sort | Thierry Defrance |
| collection | Directory of Open Access Books |
| description | Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases. |
| format | Online |
| id | doab-20.500.12854ir-55432 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-554322024-03-30T23:22:54Z The Origin of the Plasma Cell Heterogeneity Thierry Defrance Catherine Pellat-Deceunynck R5-920 RC581-607 IL21 Autoimmunity differentiation Cell Cycle B-cell Plasma cell Myeloma Autophagy B1 thema EDItEUR::M Medicine and Nursing Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the “active” in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases. 2021-02-11T21:54:25Z 2021-02-11T21:54:25Z 2016-04-07 11:22:02 2015 book 18857 16648714 9782889197347 https://directory.doabooks.org/handle/20.500.12854/55432 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Origin_of_the_Plasma_Cell_Heterogeneity/753 http://journal.frontiersin.org/researchtopic/1504/the-origin-of-the-plasma-cell-heterogeneity Frontiers Media SA 10.3389/978-2-88919-734-7 10.3389/978-2-88919-734-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197347 80 open access |
| spellingShingle | R5-920 RC581-607 IL21 Autoimmunity differentiation Cell Cycle B-cell Plasma cell Myeloma Autophagy B1 thema EDItEUR::M Medicine and Nursing Thierry Defrance Catherine Pellat-Deceunynck The Origin of the Plasma Cell Heterogeneity |
| title | The Origin of the Plasma Cell Heterogeneity |
| title_full | The Origin of the Plasma Cell Heterogeneity |
| title_fullStr | The Origin of the Plasma Cell Heterogeneity |
| title_full_unstemmed | The Origin of the Plasma Cell Heterogeneity |
| title_short | The Origin of the Plasma Cell Heterogeneity |
| title_sort | origin of the plasma cell heterogeneity |
| topic | R5-920 RC581-607 IL21 Autoimmunity differentiation Cell Cycle B-cell Plasma cell Myeloma Autophagy B1 thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 IL21 Autoimmunity differentiation Cell Cycle B-cell Plasma cell Myeloma Autophagy B1 thema EDItEUR::M Medicine and Nursing |
| url | 18857 |
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