The origin, function and diagnostic potential of extracellular microRNA in human body fluids
Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellu...
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| Format: | Online |
| Jezik: | angleščina |
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Frontiers Media SA
2021
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| Online dostop: | 17653 |
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| _version_ | 1869513903250079744 |
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| author | William Cho Andrey Turchinovich |
| author_browse | Andrey Turchinovich William Cho |
| author_facet | William Cho Andrey Turchinovich |
| author_sort | William Cho |
| collection | Directory of Open Access Books |
| description | Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific 'by-products' of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication. |
| format | Online |
| id | doab-20.500.12854ir-55434 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-554342024-04-05T12:34:52Z The origin, function and diagnostic potential of extracellular microRNA in human body fluids William Cho Andrey Turchinovich QH426-470 Q1-390 extracellular miRNA exosomal miRNA blood plasma blood serum circulating miRNA Argonaute Proteins cell-cell communication biological fluids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Short non-coding RNA molecules, microRNAs (miRNAs), post-transcriptionally regulate gene expression in living cells. In recent years, miRNAs have been found in a wide spectrum of mammalian body fluids including blood plasma, saliva, urine, milk, seminal plasma, tears and amniotic fluid as extracellular circulating nuclease-resistant entities. The changes in miRNA spectra observed in certain fluids correlated with various pathological conditions suggesting that extracellular miRNAs can serve as informative biomarkers for certain diseases including cancer. However, the mechanism of generation and a biological role of extracellular miRNAs remain unclear. The current theories regarding extracellular miRNA origin and function suggest that these miRNAs can be either non-specific 'by-products' of cellular activity and cell death or specifically released cell-cell signaling messengers. The goal of this Research Topic is to bring together up-to-date knowledge about the extracellular miRNA and its role in disease diagnostics and, possibly, inter-cellular communication. 2021-02-11T21:55:54Z 2021-02-11T21:55:54Z 2015-11-16 15:44:59 2014 book 17653 16648714 9782889192427 https://directory.doabooks.org/handle/20.500.12854/55434 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_origin_function_and_diagnostic_potential_of_extracellular_microRNA_in_human_body_fluids/292#nogo http://journal.frontiersin.org/researchtopic/1100/the-origin-function-and-diagnostic-potential-of-extracellular-microrna-in-human-body-fluids Frontiers Media SA 10.3389/978-2-88919-242-7 10.3389/978-2-88919-242-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192427 114 open access |
| spellingShingle | QH426-470 Q1-390 extracellular miRNA exosomal miRNA blood plasma blood serum circulating miRNA Argonaute Proteins cell-cell communication biological fluids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) William Cho Andrey Turchinovich The origin, function and diagnostic potential of extracellular microRNA in human body fluids |
| title | The origin, function and diagnostic potential of extracellular microRNA in human body fluids |
| title_full | The origin, function and diagnostic potential of extracellular microRNA in human body fluids |
| title_fullStr | The origin, function and diagnostic potential of extracellular microRNA in human body fluids |
| title_full_unstemmed | The origin, function and diagnostic potential of extracellular microRNA in human body fluids |
| title_short | The origin, function and diagnostic potential of extracellular microRNA in human body fluids |
| title_sort | origin function and diagnostic potential of extracellular microrna in human body fluids |
| topic | QH426-470 Q1-390 extracellular miRNA exosomal miRNA blood plasma blood serum circulating miRNA Argonaute Proteins cell-cell communication biological fluids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 Q1-390 extracellular miRNA exosomal miRNA blood plasma blood serum circulating miRNA Argonaute Proteins cell-cell communication biological fluids thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 17653 |
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