Parkinson's Disease Cell Vulnerability and Disease Progression
Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of P...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Online |
| Language: | English |
| Published: |
Frontiers Media SA
2021
|
| Subjects: | |
| Online Access: | 18808 |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1869514721866022912 |
|---|---|
| author | Jose A. Obeso Javier Blesa Jose L. Lanciego |
| author_browse | Javier Blesa Jose A. Obeso Jose L. Lanciego |
| author_facet | Jose A. Obeso Javier Blesa Jose L. Lanciego |
| author_sort | Jose A. Obeso |
| collection | Directory of Open Access Books |
| description | Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease. |
| format | Online |
| id | doab-20.500.12854ir-55673 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-556732024-04-05T12:35:25Z Parkinson's Disease Cell Vulnerability and Disease Progression Jose A. Obeso Javier Blesa Jose L. Lanciego RC321-571 Q1-390 Striatum synuclein Mitochondria Cell vulnerability Dopamine Substantia Nigra Dopaminergic Neurons Parkinson's Disease habitual behavior thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease. 2021-02-11T22:11:32Z 2021-02-11T22:11:32Z 2016-04-07 11:22:02 2015 book 18808 16648714 9782889196760 https://directory.doabooks.org/handle/20.500.12854/55673 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Parkinson_s_Disease_Cell_Vulnerability_and_Disease_Progression/754 http://journal.frontiersin.org/researchtopic/2033/parkinsons-disease-cell-vulnerability-and-disease-progression Frontiers Media SA 10.3389/978-2-88919-676-0 10.3389/978-2-88919-676-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196760 194 open access |
| spellingShingle | RC321-571 Q1-390 Striatum synuclein Mitochondria Cell vulnerability Dopamine Substantia Nigra Dopaminergic Neurons Parkinson's Disease habitual behavior thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Jose A. Obeso Javier Blesa Jose L. Lanciego Parkinson's Disease Cell Vulnerability and Disease Progression |
| title | Parkinson's Disease Cell Vulnerability and Disease Progression |
| title_full | Parkinson's Disease Cell Vulnerability and Disease Progression |
| title_fullStr | Parkinson's Disease Cell Vulnerability and Disease Progression |
| title_full_unstemmed | Parkinson's Disease Cell Vulnerability and Disease Progression |
| title_short | Parkinson's Disease Cell Vulnerability and Disease Progression |
| title_sort | parkinson s disease cell vulnerability and disease progression |
| topic | RC321-571 Q1-390 Striatum synuclein Mitochondria Cell vulnerability Dopamine Substantia Nigra Dopaminergic Neurons Parkinson's Disease habitual behavior thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Striatum synuclein Mitochondria Cell vulnerability Dopamine Substantia Nigra Dopaminergic Neurons Parkinson's Disease habitual behavior thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18808 |
| work_keys_str_mv | AT joseaobeso parkinsonsdiseasecellvulnerabilityanddiseaseprogression AT javierblesa parkinsonsdiseasecellvulnerabilityanddiseaseprogression AT josellanciego parkinsonsdiseasecellvulnerabilityanddiseaseprogression |