Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic
The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of dise...
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| Autores principales: | , , |
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| Formato: | Online |
| Lenguaje: | inglés |
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Frontiers Media SA
2021
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| Acceso en línea: | 25622 |
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| _version_ | 1869529191909687296 |
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| author | Olivier Darbin Daniela Andres Marcelo Merello |
| author_browse | Daniela Andres Marcelo Merello Olivier Darbin |
| author_facet | Olivier Darbin Daniela Andres Marcelo Merello |
| author_sort | Olivier Darbin |
| collection | Directory of Open Access Books |
| description | The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders. |
| format | Online |
| id | doab-20.500.12854ir-55792 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-557922024-04-05T17:30:09Z Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic Olivier Darbin Daniela Andres Marcelo Merello RC321-571 Q1-390 Braak's hypothesis basal ganglia Parkinson's disease cycling movement disorders computational modeling Huntington's disease non-motor symptoms nonlinear dynamics deep brain stimulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders. 2021-02-11T22:20:56Z 2021-02-11T22:20:56Z 2018-02-27 16:16:45 2017 book 25622 16648714 9782889453177 https://directory.doabooks.org/handle/20.500.12854/55792 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/books/Pathophysiology_of_the_Basal_Ganglia_and_Movement_Disorders_Gaining_New_Insights_from_Modeling_and_/1365 https://www.frontiersin.org/research-topics/3875/pathophysiology-of-the-basal-ganglia-and-movement-disorders-gaining-new-insights-from-modeling-and-e Frontiers Media SA 10.3389/978-2-88945-317-7 10.3389/978-2-88945-317-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889453177 220 open access |
| spellingShingle | RC321-571 Q1-390 Braak's hypothesis basal ganglia Parkinson's disease cycling movement disorders computational modeling Huntington's disease non-motor symptoms nonlinear dynamics deep brain stimulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Olivier Darbin Daniela Andres Marcelo Merello Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
| title | Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
| title_full | Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
| title_fullStr | Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
| title_full_unstemmed | Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
| title_short | Pathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic |
| title_sort | pathophysiology of the basal ganglia and movement disorders gaining new insights from modeling and experimentation to influence the clinic |
| topic | RC321-571 Q1-390 Braak's hypothesis basal ganglia Parkinson's disease cycling movement disorders computational modeling Huntington's disease non-motor symptoms nonlinear dynamics deep brain stimulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Braak's hypothesis basal ganglia Parkinson's disease cycling movement disorders computational modeling Huntington's disease non-motor symptoms nonlinear dynamics deep brain stimulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 25622 |
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