Pattern recognition receptors and cancer
The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general fe...
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| 主要な著者: | , |
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| フォーマット: | Online |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media SA
2021
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| 主題: | |
| オンライン･アクセス: | 19572 |
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| _version_ | 1869515675955888128 |
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| author | Anton G. Kutikhin Arseniy E. Yuzhalin |
| author_browse | Anton G. Kutikhin Arseniy E. Yuzhalin |
| author_facet | Anton G. Kutikhin Arseniy E. Yuzhalin |
| author_sort | Anton G. Kutikhin |
| collection | Directory of Open Access Books |
| description | The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field. |
| format | Online |
| id | doab-20.500.12854ir-55828 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-558282024-03-30T23:21:46Z Pattern recognition receptors and cancer Anton G. Kutikhin Arseniy E. Yuzhalin R5-920 RC581-607 Toll-Like Receptors C-type lectin receptors nod-like receptors DNA Repair Pattern Recognition Receptors Inflammation RIG-I-like receptors Autophagy Cancer Apoptosis thema EDItEUR::M Medicine and Nursing The group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field. 2021-02-11T22:23:34Z 2021-02-11T22:23:34Z 2016-08-16 10:34:25 2015 book 19572 16648714 9782889196746 https://directory.doabooks.org/handle/20.500.12854/55828 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Pattern_Recognition_Receptors_and_Cancer/699 http://journal.frontiersin.org/researchtopic/1919/pattern-recognition-receptors-and-cancer Frontiers Media SA 10.3389/978-2-88919-674-6 10.3389/978-2-88919-674-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196746 201 open access |
| spellingShingle | R5-920 RC581-607 Toll-Like Receptors C-type lectin receptors nod-like receptors DNA Repair Pattern Recognition Receptors Inflammation RIG-I-like receptors Autophagy Cancer Apoptosis thema EDItEUR::M Medicine and Nursing Anton G. Kutikhin Arseniy E. Yuzhalin Pattern recognition receptors and cancer |
| title | Pattern recognition receptors and cancer |
| title_full | Pattern recognition receptors and cancer |
| title_fullStr | Pattern recognition receptors and cancer |
| title_full_unstemmed | Pattern recognition receptors and cancer |
| title_short | Pattern recognition receptors and cancer |
| title_sort | pattern recognition receptors and cancer |
| topic | R5-920 RC581-607 Toll-Like Receptors C-type lectin receptors nod-like receptors DNA Repair Pattern Recognition Receptors Inflammation RIG-I-like receptors Autophagy Cancer Apoptosis thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Toll-Like Receptors C-type lectin receptors nod-like receptors DNA Repair Pattern Recognition Receptors Inflammation RIG-I-like receptors Autophagy Cancer Apoptosis thema EDItEUR::M Medicine and Nursing |
| url | 19572 |
| work_keys_str_mv | AT antongkutikhin patternrecognitionreceptorsandcancer AT arseniyeyuzhalin patternrecognitionreceptorsandcancer |