Perivascular Adipose Tissue (PVAT) in Health and Disease

In 1991, Soltis and Cassis (Clin Exp Hypertens A 1991 13:277-296) published the first paper that the fat tissue around an artery – perivascular adipose tissue or PVAT – changed how the artery contracted to norepinephrine. Followed later by important work showing that PVAT itself contained vasoactive...

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Egile Nagusiak: Maik Gollasch, Stephanie W. Watts
Formatua: Online
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Argitaratua: Frontiers Media SA 2021
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author Maik Gollasch
Stephanie W. Watts
author_browse Maik Gollasch
Stephanie W. Watts
author_facet Maik Gollasch
Stephanie W. Watts
author_sort Maik Gollasch
collection Directory of Open Access Books
description In 1991, Soltis and Cassis (Clin Exp Hypertens A 1991 13:277-296) published the first paper that the fat tissue around an artery – perivascular adipose tissue or PVAT – changed how the artery contracted to norepinephrine. Followed later by important work showing that PVAT itself contained vasoactive molecules, the scientific community recognized that PVAT was not simply a store of fat but is a vasoactive tissue that contributes to the functioning and status of the vessel it surrounds. Our goal for this Frontiers Research Topic is to highlight the significant reach of PVAT in vascular function, from contractility to growth in health and in disease. In doing so, we explicitly place findings that can be taken advantage of in creating new therapies for cardiovascular diseases that continue to challenge our community. These include hypertension, atherosclerosis, and diabetes to name a few.
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spelling doab-20.500.12854ir-560232024-03-31T22:45:08Z Perivascular Adipose Tissue (PVAT) in Health and Disease Maik Gollasch Stephanie W. Watts QP1-981 Q1-390 atherosclerosis cardiovascular disease contractility vein graft aging PVAT hypertension obesity thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology In 1991, Soltis and Cassis (Clin Exp Hypertens A 1991 13:277-296) published the first paper that the fat tissue around an artery – perivascular adipose tissue or PVAT – changed how the artery contracted to norepinephrine. Followed later by important work showing that PVAT itself contained vasoactive molecules, the scientific community recognized that PVAT was not simply a store of fat but is a vasoactive tissue that contributes to the functioning and status of the vessel it surrounds. Our goal for this Frontiers Research Topic is to highlight the significant reach of PVAT in vascular function, from contractility to growth in health and in disease. In doing so, we explicitly place findings that can be taken advantage of in creating new therapies for cardiovascular diseases that continue to challenge our community. These include hypertension, atherosclerosis, and diabetes to name a few. 2021-02-11T22:36:26Z 2021-02-11T22:36:26Z 2019-01-23 14:53:43 2018 book 32002 16648714 9782889456031 https://directory.doabooks.org/handle/20.500.12854/56023 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5698/perivascular-adipose-tissue-pvat-in-health-and-disease Frontiers Media SA 10.3389/978-2-88945-603-1 10.3389/978-2-88945-603-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456031 158 open access
spellingShingle QP1-981
Q1-390
atherosclerosis
cardiovascular disease
contractility
vein graft
aging
PVAT
hypertension
obesity
thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
Maik Gollasch
Stephanie W. Watts
Perivascular Adipose Tissue (PVAT) in Health and Disease
title Perivascular Adipose Tissue (PVAT) in Health and Disease
title_full Perivascular Adipose Tissue (PVAT) in Health and Disease
title_fullStr Perivascular Adipose Tissue (PVAT) in Health and Disease
title_full_unstemmed Perivascular Adipose Tissue (PVAT) in Health and Disease
title_short Perivascular Adipose Tissue (PVAT) in Health and Disease
title_sort perivascular adipose tissue pvat in health and disease
topic QP1-981
Q1-390
atherosclerosis
cardiovascular disease
contractility
vein graft
aging
PVAT
hypertension
obesity
thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
topic_facet QP1-981
Q1-390
atherosclerosis
cardiovascular disease
contractility
vein graft
aging
PVAT
hypertension
obesity
thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
url 32002
work_keys_str_mv AT maikgollasch perivascularadiposetissuepvatinhealthanddisease
AT stephaniewwatts perivascularadiposetissuepvatinhealthanddisease