Pharmaceutical Crystals
The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutic...
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| Автори: | , |
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| Формат: | Online |
| Мова: | Англійська |
| Опубліковано: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Предмети: | |
| Онлайн доступ: | 45988 |
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| _version_ | 1869516031450415104 |
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| author | Uekusa, Hidehiro Yonemochi, Etsuo |
| author_browse | Uekusa, Hidehiro Yonemochi, Etsuo |
| author_facet | Uekusa, Hidehiro Yonemochi, Etsuo |
| author_sort | Uekusa, Hidehiro |
| collection | Directory of Open Access Books |
| description | The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals. |
| format | Online |
| id | doab-20.500.12854ir-56130 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-561302024-04-05T12:38:51Z Pharmaceutical Crystals Uekusa, Hidehiro Yonemochi, Etsuo QD1-999 Q1-390 QD450-801 crystal structure analysis n/a famotidine solution crystallization salt optimization structure determination from powder diffraction data Hirshfeld surface analysis DFT molecular docking study melting diagram dehydration hygroscopicity HBV Benzodioxole pharmaceutical crystals 4-b]indol-4-one pyrimidin-4(3H)-one liquid assisted grinding HOMO-LUMO dissolution cocrystal formation Raman spectroscopy carbamazepine hydrogen bonding 3 ondansetron physicochemical properties solubility succinic acid cocrystal adefovir dipivoxil hepatitis B polymorphs hydrogen-bond-acceptance ability DFT study Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt photostability on-line monitoring 5-dihydro-4H-pyrimido[5 Imidazole Semicarbazone crystal habit Crystal structure solvent-mediated polymorphic transformation ticagrelor hydrate pharmaceutical cocrystal malonic acid 1H-indole reactivity descriptors famoxadone crystal structure dicarboxylic acid hydrogen bond saccharin thema EDItEUR::P Mathematics and Science::PN Chemistry The crystalline state is the most commonly used essential solid active pharmaceutical ingredient (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines, but the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. This book entitled “Pharmaceutical Crystals"" focuses on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts, and hydrates, and polymorph crystals are reported. Such crystal structures were investigated in the latest studies that combined morphology, spectroscopic, theoretical calculation, and thermal analysis with crystallographic study. This book highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure–property study of pharmaceutical crystals. The Guest Editors of this book hope the readers enjoy a wide variety of recent studies on Pharmaceutical Crystals. 2021-02-11T22:44:34Z 2021-02-11T22:44:34Z 2020-06-09 16:38:57 2020 book 45988 9783039287123 9783039287130 https://directory.doabooks.org/handle/20.500.12854/56130 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2162 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-713-0 10.3390/books978-3-03928-713-0 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039287123 9783039287130 148 open access |
| spellingShingle | QD1-999 Q1-390 QD450-801 crystal structure analysis n/a famotidine solution crystallization salt optimization structure determination from powder diffraction data Hirshfeld surface analysis DFT molecular docking study melting diagram dehydration hygroscopicity HBV Benzodioxole pharmaceutical crystals 4-b]indol-4-one pyrimidin-4(3H)-one liquid assisted grinding HOMO-LUMO dissolution cocrystal formation Raman spectroscopy carbamazepine hydrogen bonding 3 ondansetron physicochemical properties solubility succinic acid cocrystal adefovir dipivoxil hepatitis B polymorphs hydrogen-bond-acceptance ability DFT study Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt photostability on-line monitoring 5-dihydro-4H-pyrimido[5 Imidazole Semicarbazone crystal habit Crystal structure solvent-mediated polymorphic transformation ticagrelor hydrate pharmaceutical cocrystal malonic acid 1H-indole reactivity descriptors famoxadone crystal structure dicarboxylic acid hydrogen bond saccharin thema EDItEUR::P Mathematics and Science::PN Chemistry Uekusa, Hidehiro Yonemochi, Etsuo Pharmaceutical Crystals |
| title | Pharmaceutical Crystals |
| title_full | Pharmaceutical Crystals |
| title_fullStr | Pharmaceutical Crystals |
| title_full_unstemmed | Pharmaceutical Crystals |
| title_short | Pharmaceutical Crystals |
| title_sort | pharmaceutical crystals |
| topic | QD1-999 Q1-390 QD450-801 crystal structure analysis n/a famotidine solution crystallization salt optimization structure determination from powder diffraction data Hirshfeld surface analysis DFT molecular docking study melting diagram dehydration hygroscopicity HBV Benzodioxole pharmaceutical crystals 4-b]indol-4-one pyrimidin-4(3H)-one liquid assisted grinding HOMO-LUMO dissolution cocrystal formation Raman spectroscopy carbamazepine hydrogen bonding 3 ondansetron physicochemical properties solubility succinic acid cocrystal adefovir dipivoxil hepatitis B polymorphs hydrogen-bond-acceptance ability DFT study Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt photostability on-line monitoring 5-dihydro-4H-pyrimido[5 Imidazole Semicarbazone crystal habit Crystal structure solvent-mediated polymorphic transformation ticagrelor hydrate pharmaceutical cocrystal malonic acid 1H-indole reactivity descriptors famoxadone crystal structure dicarboxylic acid hydrogen bond saccharin thema EDItEUR::P Mathematics and Science::PN Chemistry |
| topic_facet | QD1-999 Q1-390 QD450-801 crystal structure analysis n/a famotidine solution crystallization salt optimization structure determination from powder diffraction data Hirshfeld surface analysis DFT molecular docking study melting diagram dehydration hygroscopicity HBV Benzodioxole pharmaceutical crystals 4-b]indol-4-one pyrimidin-4(3H)-one liquid assisted grinding HOMO-LUMO dissolution cocrystal formation Raman spectroscopy carbamazepine hydrogen bonding 3 ondansetron physicochemical properties solubility succinic acid cocrystal adefovir dipivoxil hepatitis B polymorphs hydrogen-bond-acceptance ability DFT study Nitrofurantoin–4-dimethylaminopyridine (NF-DMAP) salt photostability on-line monitoring 5-dihydro-4H-pyrimido[5 Imidazole Semicarbazone crystal habit Crystal structure solvent-mediated polymorphic transformation ticagrelor hydrate pharmaceutical cocrystal malonic acid 1H-indole reactivity descriptors famoxadone crystal structure dicarboxylic acid hydrogen bond saccharin thema EDItEUR::P Mathematics and Science::PN Chemistry |
| url | 45988 |
| work_keys_str_mv | AT uekusahidehiro pharmaceuticalcrystals AT yonemochietsuo pharmaceuticalcrystals |