Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor
Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing recepto...
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| Κύριος συγγραφέας: | |
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| Μορφή: | Online |
| Γλώσσα: | Αγγλικά |
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Frontiers Media SA
2021
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| Θέματα: | |
| Διαθέσιμο Online: | 31922 |
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| _version_ | 1869513798971293696 |
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| author | Enikö Kallay |
| author_browse | Enikö Kallay |
| author_facet | Enikö Kallay |
| author_sort | Enikö Kallay |
| collection | Directory of Open Access Books |
| description | Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR. |
| format | Online |
| id | doab-20.500.12854ir-56243 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-562432024-03-31T22:45:04Z Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor Enikö Kallay QP1-981 Q1-390 proliferation and differentiation metastasis vitamin D G protein-coupled receptor (GPCR) crystal structure parathyroid hormone (PTH) cancer Alzheimer thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Calcium is vital for human physiology; it mediates multiple signaling cascades, critical for cell survival, differentiation, or death both as first and as second messenger. The role of calcium as first messenger is mediated by the G-protein coupled receptor, the extracellular calcium-sensing receptor (CaSR). The CaSR is a multifaceted molecule that senses changes in the concentration of a wide variety of environmental factors including di- and trivalent cations, amino acids, polyamines, and pH. In calcitropic tissues with obvious roles in calcium homeostasis such as parathyroid, kidney, and bone it regulates circulating calcium concentrations. The germline mutations of the CaSR cause parathyroid disorders demonstrating the importance of the CaSR for the maintenance of serum calcium homeostasis. The CaSR has an important role also in a range of non-calcitropic tissues, such as the intestine, lungs, central and peripheral nervous system, breast, skin and reproductive system, where it regulates molecular and cellular processes such as gene expression, proliferation, differentiation and apoptosis; as well as regulating hormone secretion and lactation. This Research Topic is an overview of the CaSR and its molecular signaling properties together with the various organ systems where it plays an important role. The articles highlight the current knowledge regarding many aspects of the calcitropic and non-calcitropic physiology and pathophysiology of the CaSR. 2021-02-11T22:55:03Z 2021-02-11T22:55:03Z 2019-01-23 14:53:42 2018 book 31922 16648714 9782889455126 https://directory.doabooks.org/handle/20.500.12854/56243 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4063/physiology-and-pathophysiology-of-the-extracellular-calcium-sensing-receptor Frontiers Media SA 10.3389/978-2-88945-512-6 10.3389/978-2-88945-512-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455126 189 open access |
| spellingShingle | QP1-981 Q1-390 proliferation and differentiation metastasis vitamin D G protein-coupled receptor (GPCR) crystal structure parathyroid hormone (PTH) cancer Alzheimer thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Enikö Kallay Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
| title | Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
| title_full | Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
| title_fullStr | Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
| title_full_unstemmed | Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
| title_short | Physiology and Pathophysiology of the Extracellular Calcium-Sensing Receptor |
| title_sort | physiology and pathophysiology of the extracellular calcium sensing receptor |
| topic | QP1-981 Q1-390 proliferation and differentiation metastasis vitamin D G protein-coupled receptor (GPCR) crystal structure parathyroid hormone (PTH) cancer Alzheimer thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 proliferation and differentiation metastasis vitamin D G protein-coupled receptor (GPCR) crystal structure parathyroid hormone (PTH) cancer Alzheimer thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 31922 |
| work_keys_str_mv | AT enikokallay physiologyandpathophysiologyoftheextracellularcalciumsensingreceptor |