Podocyte Pathology and Nephropathy
The understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and AR...
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| 主要な著者: | , |
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| フォーマット: | Online |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media SA
2021
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| 主題: | |
| オンライン･アクセス: | 18832 |
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| _version_ | 1869521567375949824 |
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| author | Maciej Wojciech Jankowski Gavin Iain Welsh |
| author_browse | Gavin Iain Welsh Maciej Wojciech Jankowski |
| author_facet | Maciej Wojciech Jankowski Gavin Iain Welsh |
| author_sort | Maciej Wojciech Jankowski |
| collection | Directory of Open Access Books |
| description | The understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and ARBs on the progression of nephropathy, the emergence of new biomarkers such as Cystatin and the role of cytokines, inflammatory molecules and adhesion molecules. Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions. Presented in this e-book articles highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process. |
| format | Online |
| id | doab-20.500.12854ir-56451 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-564512022-01-31T10:13:38Z Podocyte Pathology and Nephropathy Maciej Wojciech Jankowski Gavin Iain Welsh RC648-665 R5-920 glomeruli Podocytes foot processes kidney disease Exosomes diabetes Proteinuria The understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and ARBs on the progression of nephropathy, the emergence of new biomarkers such as Cystatin and the role of cytokines, inflammatory molecules and adhesion molecules. Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions. Presented in this e-book articles highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process. 2021-02-11T23:13:01Z 2021-02-11T23:13:01Z 2016-04-07 11:22:02 2015 book 18832 16648714 9782889197101 https://directory.doabooks.org/handle/20.500.12854/56451 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Podocyte_Pathology_and_Nephropathy/728 http://journal.frontiersin.org/researchtopic/1865/podocyte-pathology-and-nephropathy Frontiers Media SA 10.3389/978-2-88919-710-1 10.3389/978-2-88919-710-1 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197101 96 open access |
| spellingShingle | RC648-665 R5-920 glomeruli Podocytes foot processes kidney disease Exosomes diabetes Proteinuria Maciej Wojciech Jankowski Gavin Iain Welsh Podocyte Pathology and Nephropathy |
| title | Podocyte Pathology and Nephropathy |
| title_full | Podocyte Pathology and Nephropathy |
| title_fullStr | Podocyte Pathology and Nephropathy |
| title_full_unstemmed | Podocyte Pathology and Nephropathy |
| title_short | Podocyte Pathology and Nephropathy |
| title_sort | podocyte pathology and nephropathy |
| topic | RC648-665 R5-920 glomeruli Podocytes foot processes kidney disease Exosomes diabetes Proteinuria |
| topic_facet | RC648-665 R5-920 glomeruli Podocytes foot processes kidney disease Exosomes diabetes Proteinuria |
| url | 18832 |
| work_keys_str_mv | AT maciejwojciechjankowski podocytepathologyandnephropathy AT gaviniainwelsh podocytepathologyandnephropathy |