PPARs in Cellular and Whole Body Energy Metabolism
At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny!...
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| Formato: | Online |
| Idioma: | inglês |
| Publicado em: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Acesso em linha: | 29833 |
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| _version_ | 1869525844076003328 |
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| author | Walter Wahli (Ed.) Rachel Tee (Ed.) |
| author_browse | Rachel Tee (Ed.) Walter Wahli (Ed.) |
| author_facet | Walter Wahli (Ed.) Rachel Tee (Ed.) |
| author_sort | Walter Wahli (Ed.) |
| collection | Directory of Open Access Books |
| description | At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny! However, there is more to energy balance than alterations in body weight. In the 1990s, it was found that fatty acids not only function as fuel molecules only, but also serve as signaling molecules. They bind nuclear hormone receptors, the Peroxisome Proliferator-Activated Receptors, commonly referred to by the acronym PPARs. PPARs are transcription factors that directly control the expression of genes of metabolism, thereby impacting a multitude of pathways crucial for whole body physiology. PPARs are also activated by synthetic agonists, which are drugs used for lowering triglycerides and blood sugar. This book features articles that address tools for the identification of novel PPAR ligands, as well as the roles of the receptors in several organs, such as the brain, heart, liver, adipose tissue, gut, and muscle. As such, this book documents the multifaceted roles of these nuclear receptors that continue to attract significant attention, not least because of their still not fully realized potential to treat several health conditions. |
| format | Online |
| id | doab-20.500.12854ir-56800 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-568002024-04-05T12:35:08Z PPARs in Cellular and Whole Body Energy Metabolism Walter Wahli (Ed.) Rachel Tee (Ed.) QH426-470 QH301-705.5 Ligand identification Peroxisome Proliferator-Activated Receptors (PPARs) Energy homeostasis Metabolic diseases Metabolic regulations Tumor development thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) At no other time in its history has humankind been as concerned about good health. Lifestyle habits are promoted as indispensable allies for the daily prevention against so-called metabolic diseases. Paradoxically, the world has never been so obese, while the beauty canons have never been so skinny! However, there is more to energy balance than alterations in body weight. In the 1990s, it was found that fatty acids not only function as fuel molecules only, but also serve as signaling molecules. They bind nuclear hormone receptors, the Peroxisome Proliferator-Activated Receptors, commonly referred to by the acronym PPARs. PPARs are transcription factors that directly control the expression of genes of metabolism, thereby impacting a multitude of pathways crucial for whole body physiology. PPARs are also activated by synthetic agonists, which are drugs used for lowering triglycerides and blood sugar. This book features articles that address tools for the identification of novel PPAR ligands, as well as the roles of the receptors in several organs, such as the brain, heart, liver, adipose tissue, gut, and muscle. As such, this book documents the multifaceted roles of these nuclear receptors that continue to attract significant attention, not least because of their still not fully realized potential to treat several health conditions. 2021-02-11T23:39:19Z 2021-02-11T23:39:19Z 2019-01-09 11:12:08 2019 book 29833 9783038974628 9783038974611 https://directory.doabooks.org/handle/20.500.12854/56800 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://play.google.com/books/publish/a/14935057684283403269#details/ISBN:9783038974611 https://www.mdpi.com/books/pdfview/book/1079 https://www.mdpi.com/books/pdfview/book/1079 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-462-8 10.3390/books978-3-03897-462-8 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038974628 9783038974611 582 open access |
| spellingShingle | QH426-470 QH301-705.5 Ligand identification Peroxisome Proliferator-Activated Receptors (PPARs) Energy homeostasis Metabolic diseases Metabolic regulations Tumor development thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) Walter Wahli (Ed.) Rachel Tee (Ed.) PPARs in Cellular and Whole Body Energy Metabolism |
| title | PPARs in Cellular and Whole Body Energy Metabolism |
| title_full | PPARs in Cellular and Whole Body Energy Metabolism |
| title_fullStr | PPARs in Cellular and Whole Body Energy Metabolism |
| title_full_unstemmed | PPARs in Cellular and Whole Body Energy Metabolism |
| title_short | PPARs in Cellular and Whole Body Energy Metabolism |
| title_sort | ppars in cellular and whole body energy metabolism |
| topic | QH426-470 QH301-705.5 Ligand identification Peroxisome Proliferator-Activated Receptors (PPARs) Energy homeostasis Metabolic diseases Metabolic regulations Tumor development thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| topic_facet | QH426-470 QH301-705.5 Ligand identification Peroxisome Proliferator-Activated Receptors (PPARs) Energy homeostasis Metabolic diseases Metabolic regulations Tumor development thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical) |
| url | 29833 |
| work_keys_str_mv | AT walterwahlied pparsincellularandwholebodyenergymetabolism AT rachelteeed pparsincellularandwholebodyenergymetabolism |