Precision Medicine in Oncology
The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move t...
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| Glavni autori: | , , , |
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| Format: | Online |
| Jezik: | engleski |
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Frontiers Media SA
2021
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| Teme: | |
| Online pristup: | 32074 |
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| _version_ | 1869525167510650880 |
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| author | Andrea Lunardi Angela Re Caterina Nardella Alessandro Quattrone |
| author_browse | Alessandro Quattrone Andrea Lunardi Angela Re Caterina Nardella |
| author_facet | Andrea Lunardi Angela Re Caterina Nardella Alessandro Quattrone |
| author_sort | Andrea Lunardi |
| collection | Directory of Open Access Books |
| description | The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration. |
| format | Online |
| id | doab-20.500.12854ir-56871 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-568712024-03-31T13:08:32Z Precision Medicine in Oncology Andrea Lunardi Angela Re Caterina Nardella Alessandro Quattrone R5-920 RC254-282 computational biology synthetic biology pathology noncoding RNA aberration precision medicine in vivo preclinical platform oncology thema EDItEUR::M Medicine and Nursing The emerging precision medicine approach aims to tailor disease prevention and treatment to each patient on the basis of individual variability, environmental factors and lifestyle. Fundamental achievements in the last few decades have converged to offer nowadays the compelling opportunity to move towards this innovative approach: i) unprecedented improvements in disease modeling in silico, in vitro and in vivo; ii) acquisition of a wide range of biomedical information combined with the development of computational toolsets for flexible and integrative analyses of multi-assay datasets. Our deeper understanding of oncogenic mechanisms has finally begun to have a crucial impact on clinical decisions at several steps, from cancer prevention and diagnosis to therapeutic intervention. However, precision oncology still encounters several unresolved hurdles including tumour heterogeneity and recurrence as well as unexplained drug resistance and lack of effective ways to monitor response to therapeutic treatments. Notably, limitations in biomedical research regulation and governance represent additional debatable issues that need careful consideration. 2021-02-11T23:45:01Z 2021-02-11T23:45:01Z 2019-01-23 14:53:43 2019 book 32074 16648714 9782889457052 https://directory.doabooks.org/handle/20.500.12854/56871 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5536/precision-medicine-in-oncology Frontiers Media SA 10.3389/978-2-88945-705-2 10.3389/978-2-88945-705-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889457052 163 open access |
| spellingShingle | R5-920 RC254-282 computational biology synthetic biology pathology noncoding RNA aberration precision medicine in vivo preclinical platform oncology thema EDItEUR::M Medicine and Nursing Andrea Lunardi Angela Re Caterina Nardella Alessandro Quattrone Precision Medicine in Oncology |
| title | Precision Medicine in Oncology |
| title_full | Precision Medicine in Oncology |
| title_fullStr | Precision Medicine in Oncology |
| title_full_unstemmed | Precision Medicine in Oncology |
| title_short | Precision Medicine in Oncology |
| title_sort | precision medicine in oncology |
| topic | R5-920 RC254-282 computational biology synthetic biology pathology noncoding RNA aberration precision medicine in vivo preclinical platform oncology thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 computational biology synthetic biology pathology noncoding RNA aberration precision medicine in vivo preclinical platform oncology thema EDItEUR::M Medicine and Nursing |
| url | 32074 |
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