Progenitor diversity and neural cell specification in the central nervous system
The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons...
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| প্রধান লেখক: | , , |
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
Frontiers Media SA
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 18813 |
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| _version_ | 1869530187269406720 |
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| author | Marcos R. Costa Cecilia Hedin-Pereira Caroline Rouaux |
| author_browse | Caroline Rouaux Cecilia Hedin-Pereira Marcos R. Costa |
| author_facet | Marcos R. Costa Cecilia Hedin-Pereira Caroline Rouaux |
| author_sort | Marcos R. Costa |
| collection | Directory of Open Access Books |
| description | The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential. |
| format | Online |
| id | doab-20.500.12854ir-57138 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-571382024-04-05T17:30:19Z Progenitor diversity and neural cell specification in the central nervous system Marcos R. Costa Cecilia Hedin-Pereira Caroline Rouaux RC321-571 Q1-390 Fate Restriction Central Nervous System Neurons Astrocytes Extrinsic Signals neural progenitors specification Transcription Factors oligodendrocytes neurogenic niches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential. 2021-02-12T00:08:30Z 2021-02-12T00:08:30Z 2016-04-07 11:22:02 2015 book 18813 16648714 9782889196838 https://directory.doabooks.org/handle/20.500.12854/57138 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Progenitor_Diversity_and_Neural_Cell_Specification_in_the_Central_Nervous_System/745#nogo http://journal.frontiersin.org/researchtopic/2297/progenitor-diversity-and-neural-cell-specification-in-the-central-nervous-system Frontiers Media SA 10.3389/978-2-88919-683-8 10.3389/978-2-88919-683-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196838 107 open access |
| spellingShingle | RC321-571 Q1-390 Fate Restriction Central Nervous System Neurons Astrocytes Extrinsic Signals neural progenitors specification Transcription Factors oligodendrocytes neurogenic niches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Marcos R. Costa Cecilia Hedin-Pereira Caroline Rouaux Progenitor diversity and neural cell specification in the central nervous system |
| title | Progenitor diversity and neural cell specification in the central nervous system |
| title_full | Progenitor diversity and neural cell specification in the central nervous system |
| title_fullStr | Progenitor diversity and neural cell specification in the central nervous system |
| title_full_unstemmed | Progenitor diversity and neural cell specification in the central nervous system |
| title_short | Progenitor diversity and neural cell specification in the central nervous system |
| title_sort | progenitor diversity and neural cell specification in the central nervous system |
| topic | RC321-571 Q1-390 Fate Restriction Central Nervous System Neurons Astrocytes Extrinsic Signals neural progenitors specification Transcription Factors oligodendrocytes neurogenic niches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Fate Restriction Central Nervous System Neurons Astrocytes Extrinsic Signals neural progenitors specification Transcription Factors oligodendrocytes neurogenic niches thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18813 |
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