Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later...

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Hlavní autoři: Nikolaos P. Daskalakis, Rachel Yehuda
Médium: Online
Jazyk:angličtina
Vydáno: Frontiers Media SA 2021
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On-line přístup:17670
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Shrnutí:Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.