Promiscuous functions of the prion protein gene family
The cellular prion protein PrPC is a ubiquitous GPI-anchored protein. While PrPC has been the focus of intense research for its involvement in a group of neurodegenerative disorders known as transmissible spongiform encephalopathies (TSE), much less attention has been devoted to its physiological fu...
Պահպանված է:
| Հիմնական հեղինակներ: | , |
|---|---|
| Ձևաչափ: | Online |
| Լեզու: | անգլերեն |
| Հրապարակվել է: |
Frontiers Media SA
2021
|
| Խորագրեր: | |
| Առցանց հասանելիություն: | 19513 |
| Ցուցիչներ: |
Չկան պիտակներ, Եղեք առաջինը, ով նշում է այս գրառումը!
|
| _version_ | 1869521411102474240 |
|---|---|
| author | Jean-Luc Vilotte Sophie Mouillet-Richard |
| author_browse | Jean-Luc Vilotte Sophie Mouillet-Richard |
| author_facet | Jean-Luc Vilotte Sophie Mouillet-Richard |
| author_sort | Jean-Luc Vilotte |
| collection | Directory of Open Access Books |
| description | The cellular prion protein PrPC is a ubiquitous GPI-anchored protein. While PrPC has been the focus of intense research for its involvement in a group of neurodegenerative disorders known as transmissible spongiform encephalopathies (TSE), much less attention has been devoted to its physiological function. This notably relates to the lack of obvious abnormalities of mice, goat or cattle lacking PrPC. This apparently normal phenotype in these PrPC-deficient animals however contrasts with the very high degree of conservation of the prion protein gene (Prnp) in mammalian species (over 80%), and the presence of genes with similarities to Prnp in birds, reptiles, amphibians and fish. This high conservation together with its ubiquitous expression, - albeit at highest levels in the brain-, suggest that PrPC has major physiological functions. Dissecting PrPC function is further complicated by the occurrence, in mammals, of two potentially partially redundant homologues, Doppel, and Shadoo. The biological overlaps between members of the prion protein family are still under investigation and much debated. Similarly, although in vitro analyses have suggested various functions for PrPC, notably in cell death and survival processes, some have yielded conflicting results and/or discrepancies with in vivo studies. This Research Topic brings together the accumulated knowledge regarding the biological roles of the prion protein family, from the animal to the molecular scale. |
| format | Online |
| id | doab-20.500.12854ir-57181 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-571812024-04-05T12:32:40Z Promiscuous functions of the prion protein gene family Jean-Luc Vilotte Sophie Mouillet-Richard QH301-705.5 Q1-390 Stem Cells Neuroprotection Placenta abeta Aging Embryonic and Fetal Development Cell Adhesion Gonads Cell signaling prion protein thema EDItEUR::P Mathematics and Science::PS Biology, life sciences The cellular prion protein PrPC is a ubiquitous GPI-anchored protein. While PrPC has been the focus of intense research for its involvement in a group of neurodegenerative disorders known as transmissible spongiform encephalopathies (TSE), much less attention has been devoted to its physiological function. This notably relates to the lack of obvious abnormalities of mice, goat or cattle lacking PrPC. This apparently normal phenotype in these PrPC-deficient animals however contrasts with the very high degree of conservation of the prion protein gene (Prnp) in mammalian species (over 80%), and the presence of genes with similarities to Prnp in birds, reptiles, amphibians and fish. This high conservation together with its ubiquitous expression, - albeit at highest levels in the brain-, suggest that PrPC has major physiological functions. Dissecting PrPC function is further complicated by the occurrence, in mammals, of two potentially partially redundant homologues, Doppel, and Shadoo. The biological overlaps between members of the prion protein family are still under investigation and much debated. Similarly, although in vitro analyses have suggested various functions for PrPC, notably in cell death and survival processes, some have yielded conflicting results and/or discrepancies with in vivo studies. This Research Topic brings together the accumulated knowledge regarding the biological roles of the prion protein family, from the animal to the molecular scale. 2021-02-12T00:10:45Z 2021-02-12T00:10:45Z 2016-08-16 10:34:25 2015 book 19513 16648714 9782889196050 https://directory.doabooks.org/handle/20.500.12854/57181 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Promiscuous_Functions_of_the_Prion_Protein_Gene_Family/645#nogo http://journal.frontiersin.org/researchtopic/2567/promiscuous-functions-of-the-prion-protein-gene-family Frontiers Media SA 10.3389/978-2-88919-605-0 10.3389/978-2-88919-605-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196050 113 open access |
| spellingShingle | QH301-705.5 Q1-390 Stem Cells Neuroprotection Placenta abeta Aging Embryonic and Fetal Development Cell Adhesion Gonads Cell signaling prion protein thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Jean-Luc Vilotte Sophie Mouillet-Richard Promiscuous functions of the prion protein gene family |
| title | Promiscuous functions of the prion protein gene family |
| title_full | Promiscuous functions of the prion protein gene family |
| title_fullStr | Promiscuous functions of the prion protein gene family |
| title_full_unstemmed | Promiscuous functions of the prion protein gene family |
| title_short | Promiscuous functions of the prion protein gene family |
| title_sort | promiscuous functions of the prion protein gene family |
| topic | QH301-705.5 Q1-390 Stem Cells Neuroprotection Placenta abeta Aging Embryonic and Fetal Development Cell Adhesion Gonads Cell signaling prion protein thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 Stem Cells Neuroprotection Placenta abeta Aging Embryonic and Fetal Development Cell Adhesion Gonads Cell signaling prion protein thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 19513 |
| work_keys_str_mv | AT jeanlucvilotte promiscuousfunctionsoftheprionproteingenefamily AT sophiemouilletrichard promiscuousfunctionsoftheprionproteingenefamily |