Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench
Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths rela...
Đã lưu trong:
| Những tác giả chính: | , |
|---|---|
| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
| Được phát hành: |
Frontiers Media SA
2021
|
| Những chủ đề: | |
| Truy cập trực tuyến: | 17746 |
| Các nhãn: |
Không có thẻ, Là người đầu tiên thẻ bản ghi này!
|
| _version_ | 1869526608948232192 |
|---|---|
| author | Scott Halstead Simona Zompi |
| author_browse | Scott Halstead Simona Zompi |
| author_facet | Scott Halstead Simona Zompi |
| author_sort | Scott Halstead |
| collection | Directory of Open Access Books |
| description | Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths related to dengue, mainly in children. Recent estimates show higher numbers, up to three times more, with 390 million estimated dengue infections per year, among which 96 million apparent infections (Bhatt et al. 2013). Initially localized to South-East Asia, dengue virus (DENV) started its spread in Latin America in the 80s. Little is known about DENV spread in Africa, but multiple seroprevalence surveys over several years are now clearly showing endemic areas in East and West Africa (Brady et al. 2013). Finally, due to global warming and intense traveling there is a risk of global spread towards more temperate regions, and both US Key islands (FL) and southern Europe recently faced DENV outbreaks. There are currently no specific treatments or vaccines available. Even though several dengue vaccines are in the pipeline, clear correlates of protection are still lacking. The recent failure of the live-attenuated Sanofi vaccine Phase 2b trial (Sabchareon et al. 2013) and the lack of correlation between clinical protection and in vitro neutralization assays, clearly underlines the necessity to better understand the role of the different components of the immune system in protection against dengue virus infection and the requirement for the development of additional and/or improved predictive assays. The aim of this research topic is to provide novel data, opinions and literature reviews on the best immune correlates of protection and recent advances in the immune response to DENV infection that can allow rapid progress of dengue vaccines. Authors can choose to submit original research papers, reviews or opinions on pre-clinical or clinical observations that will help unify the field, with perspectives from epidemiology, virology, immunology and vaccine developers. This research topic will discuss different aspects of the protective immune response to DENV that can influence vaccine development. It will include a review of epidemiological data generated in the field, which will address spatio-temporal diversity of DENV epidemics, the importance of cross-reactive protection and of the time-interval between infections as a predictor of disease. It will further include a review of the role of both the innate and adaptive immunity in DENV infection control, and discuss the usefulness of new improved animal models in dissecting the role of each immunological compartment, which will help define new correlate of immune protection. New data concerning the DENV structure and anti-dengue antibody structure will address the necessity of improved neutralization assays. The ultimate test to prove vaccine efficacy and study immune correlates of protection in humans before large trials will open up the discussion on human DENV challenges using controlled attenuated viral strains. Finally, the role of vaccines, administered in flavi-immune populations, in the modification of future epidemics will also be approached and will include novel studies on mosquitoes infection thresholds. |
| format | Online |
| id | doab-20.500.12854ir-57237 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-572372024-03-31T13:09:47Z Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench Scott Halstead Simona Zompi R5-920 RC581-607 Monocytes NK cells Dendritic Cells Dengue Antibodies protection Vaccines T cells Macrophages Immunity thema EDItEUR::M Medicine and Nursing Dengue is the most important mosquito-transmitted viral disease in humans. Half of the world population is at risk of infection, mostly in tropical and sub-tropical areas. The World Health Organization (WHO) estimates that 50 to 100 million infections occur yearly, with 50,000 to 100,000 deaths related to dengue, mainly in children. Recent estimates show higher numbers, up to three times more, with 390 million estimated dengue infections per year, among which 96 million apparent infections (Bhatt et al. 2013). Initially localized to South-East Asia, dengue virus (DENV) started its spread in Latin America in the 80s. Little is known about DENV spread in Africa, but multiple seroprevalence surveys over several years are now clearly showing endemic areas in East and West Africa (Brady et al. 2013). Finally, due to global warming and intense traveling there is a risk of global spread towards more temperate regions, and both US Key islands (FL) and southern Europe recently faced DENV outbreaks. There are currently no specific treatments or vaccines available. Even though several dengue vaccines are in the pipeline, clear correlates of protection are still lacking. The recent failure of the live-attenuated Sanofi vaccine Phase 2b trial (Sabchareon et al. 2013) and the lack of correlation between clinical protection and in vitro neutralization assays, clearly underlines the necessity to better understand the role of the different components of the immune system in protection against dengue virus infection and the requirement for the development of additional and/or improved predictive assays. The aim of this research topic is to provide novel data, opinions and literature reviews on the best immune correlates of protection and recent advances in the immune response to DENV infection that can allow rapid progress of dengue vaccines. Authors can choose to submit original research papers, reviews or opinions on pre-clinical or clinical observations that will help unify the field, with perspectives from epidemiology, virology, immunology and vaccine developers. This research topic will discuss different aspects of the protective immune response to DENV that can influence vaccine development. It will include a review of epidemiological data generated in the field, which will address spatio-temporal diversity of DENV epidemics, the importance of cross-reactive protection and of the time-interval between infections as a predictor of disease. It will further include a review of the role of both the innate and adaptive immunity in DENV infection control, and discuss the usefulness of new improved animal models in dissecting the role of each immunological compartment, which will help define new correlate of immune protection. New data concerning the DENV structure and anti-dengue antibody structure will address the necessity of improved neutralization assays. The ultimate test to prove vaccine efficacy and study immune correlates of protection in humans before large trials will open up the discussion on human DENV challenges using controlled attenuated viral strains. Finally, the role of vaccines, administered in flavi-immune populations, in the modification of future epidemics will also be approached and will include novel studies on mosquitoes infection thresholds. 2021-02-12T00:15:17Z 2021-02-12T00:15:17Z 2015-12-03 13:02:24 2015 book 17746 16648714 9782889195114 https://directory.doabooks.org/handle/20.500.12854/57237 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Protective_Immune_Response_to_Dengue_Virus_Infection_and_Vaccines_perspectives_from_the_field_to_th/493#nogo http://journal.frontiersin.org/researchtopic/1983/protective-immune-response-to-dengue-virus-infection-and-vaccines-perspectives-from-the-field-to-the Frontiers Media SA 10.3389/978-2-88919-511-4 10.3389/978-2-88919-511-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195114 97 open access |
| spellingShingle | R5-920 RC581-607 Monocytes NK cells Dendritic Cells Dengue Antibodies protection Vaccines T cells Macrophages Immunity thema EDItEUR::M Medicine and Nursing Scott Halstead Simona Zompi Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench |
| title | Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench |
| title_full | Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench |
| title_fullStr | Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench |
| title_full_unstemmed | Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench |
| title_short | Protective Immune Response to Dengue Virus Infection and Vaccines: perspectives from the field to the bench |
| title_sort | protective immune response to dengue virus infection and vaccines perspectives from the field to the bench |
| topic | R5-920 RC581-607 Monocytes NK cells Dendritic Cells Dengue Antibodies protection Vaccines T cells Macrophages Immunity thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Monocytes NK cells Dendritic Cells Dengue Antibodies protection Vaccines T cells Macrophages Immunity thema EDItEUR::M Medicine and Nursing |
| url | 17746 |
| work_keys_str_mv | AT scotthalstead protectiveimmuneresponsetodenguevirusinfectionandvaccinesperspectivesfromthefieldtothebench AT simonazompi protectiveimmuneresponsetodenguevirusinfectionandvaccinesperspectivesfromthefieldtothebench |