Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions
There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and...
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| Μορφή: | Online |
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Firenze University Press
2021
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| Διαθέσιμο Online: | 50239 |
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| _version_ | 1869516804840226816 |
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| author | Chiara Gabbiani |
| author_browse | Chiara Gabbiani |
| author_facet | Chiara Gabbiani |
| author_sort | Chiara Gabbiani |
| collection | Directory of Open Access Books |
| description | There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug–protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets. |
| format | Online |
| id | doab-20.500.12854ir-57248 |
| institution | Directory of Open Access Books |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Firenze University Press |
| publisherStr | Firenze University Press |
| record_format | ojs |
| spelling | doab-20.500.12854ir-572482024-04-05T12:32:01Z Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions Chiara Gabbiani QH301-705.5 QC1-999 Chimica Biologia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences There is considerable interest today for the reactions of anticancer metallodrugs with proteins as these interactions might feature processes that are crucial for the biodistribution, the toxicity and even the mechanism of action of this important group of anticancer agents. Valuable structural and functional information on these adducts could be derived from several biophysical studies mainly relying on the application of X-ray diffraction and ESI MS techniques. The structural and functional information achieved on the respective metallodrug–protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets. 2021-02-12T00:17:28Z 2021-02-12T00:17:28Z 2020-11-10 16:26:01 2009 book 50239 26128020 9788884539403 https://directory.doabooks.org/handle/20.500.12854/57248 Premio Tesi di Dottorato application/octet-stream Attribution-NoDerivatives 4.0 International https://www.fupress.com/isbn/9788884539403 https://www.fupress.com/redir.ashx?RetUrl=3852.pdf Firenze University Press 10.36253/978-88-8453-940-3 10.36253/978-88-8453-940-3 2ec4474d-93b1-4cfa-b313-9c6019b51b1a 9788884539403 74 open access |
| spellingShingle | QH301-705.5 QC1-999 Chimica Biologia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Chiara Gabbiani Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_full | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_fullStr | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_full_unstemmed | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_short | Proteins as possible targets for antitumor metal complexes: biophysical studies of their interactions |
| title_sort | proteins as possible targets for antitumor metal complexes biophysical studies of their interactions |
| topic | QH301-705.5 QC1-999 Chimica Biologia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 QC1-999 Chimica Biologia thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 50239 |
| work_keys_str_mv | AT chiaragabbiani proteinsaspossibletargetsforantitumormetalcomplexesbiophysicalstudiesoftheirinteractions |