Quantitative Systems Biology for Engineering Organisms and Pathways
Studying organisms as a whole for potential metabolic(ally) engineering of organisms for production of (bio)chemicals is essential for industrial biotechnology. To this end, integrative analysis of different –omics measurements (transciptomics, proteomics, metabolomics, fluxomics) provides invaluabl...
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| Formaat: | Online |
| Taal: | Engels |
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Frontiers Media SA
2021
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| Online toegang: | 18216 |
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| _version_ | 1869526622767415296 |
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| author | Alvaro R. Lara Hilal Taymaz-Nikerel |
| author_browse | Alvaro R. Lara Hilal Taymaz-Nikerel |
| author_facet | Alvaro R. Lara Hilal Taymaz-Nikerel |
| author_sort | Alvaro R. Lara |
| collection | Directory of Open Access Books |
| description | Studying organisms as a whole for potential metabolic(ally) engineering of organisms for production of (bio)chemicals is essential for industrial biotechnology. To this end, integrative analysis of different –omics measurements (transciptomics, proteomics, metabolomics, fluxomics) provides invaluable information. Combination of experimental top-down and bottom-up approaches with powerful analytical tools/techniques and mathematical modeling, namely (quantitative) systems biology, currently making the state of art of this discipline, is the only practice that would improve our understanding for the purpose. The use of high-throughput technologies induced the required development of many bioinformatics tools and mathematical methods for the integration of obtained data. Such research is significant since compiling information from different levels of a living system and connecting them is not an easy task. In particular, construction of dynamic models for product improvement has been one of the goals of many research groups. In this Research Topic, we summarize and bring a general review of the most recent and relevant contributions in quantitative systems biology applied in metabolic modeling perspective. We want to make special emphasis on the techniques that can be widely implemented in regular scientific laboratories and in those works that include theoretical presentations. With this Research Topic we discuss the importance of applying systems biology approaches for finding metabolic engineering targets for the efficient production of the desired biochemical integrating information from genomes and networks to industrial production. Examples and perspectives in the design of new industrially relevant chemicals, e.g. increased titer/productivity/yield of (bio)chemicals, are welcome. Addition to the founded examples, potential new techniques that would frontier the research will be part of this topic. The significance of multi ‘omics’ approaches to understand/uncover the pathogenesis/mechanisms of metabolic diseases is also one of the main topics. |
| format | Online |
| id | doab-20.500.12854ir-57443 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-574432024-04-11T15:10:48Z Quantitative Systems Biology for Engineering Organisms and Pathways Alvaro R. Lara Hilal Taymaz-Nikerel TP248.13-248.65 TA1-2040 Metabolic Engineering Cell factories Systems Biology thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology Studying organisms as a whole for potential metabolic(ally) engineering of organisms for production of (bio)chemicals is essential for industrial biotechnology. To this end, integrative analysis of different –omics measurements (transciptomics, proteomics, metabolomics, fluxomics) provides invaluable information. Combination of experimental top-down and bottom-up approaches with powerful analytical tools/techniques and mathematical modeling, namely (quantitative) systems biology, currently making the state of art of this discipline, is the only practice that would improve our understanding for the purpose. The use of high-throughput technologies induced the required development of many bioinformatics tools and mathematical methods for the integration of obtained data. Such research is significant since compiling information from different levels of a living system and connecting them is not an easy task. In particular, construction of dynamic models for product improvement has been one of the goals of many research groups. In this Research Topic, we summarize and bring a general review of the most recent and relevant contributions in quantitative systems biology applied in metabolic modeling perspective. We want to make special emphasis on the techniques that can be widely implemented in regular scientific laboratories and in those works that include theoretical presentations. With this Research Topic we discuss the importance of applying systems biology approaches for finding metabolic engineering targets for the efficient production of the desired biochemical integrating information from genomes and networks to industrial production. Examples and perspectives in the design of new industrially relevant chemicals, e.g. increased titer/productivity/yield of (bio)chemicals, are welcome. Addition to the founded examples, potential new techniques that would frontier the research will be part of this topic. The significance of multi ‘omics’ approaches to understand/uncover the pathogenesis/mechanisms of metabolic diseases is also one of the main topics. 2021-02-12T00:35:12Z 2021-02-12T00:35:12Z 2016-01-19 14:05:46 2016 book 18216 16648714 9782889198290 https://directory.doabooks.org/handle/20.500.12854/57443 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Quantitative_Systems_Biology_for_Engineering_Organisms_and_Pathways/887 http://journal.frontiersin.org/researchtopic/3363/quantitative-systems-biology-for-engineering-organisms-and-pathways Frontiers Media SA 10.3389/978-2-88919-829-0 10.3389/978-2-88919-829-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198290 126 open access |
| spellingShingle | TP248.13-248.65 TA1-2040 Metabolic Engineering Cell factories Systems Biology thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology Alvaro R. Lara Hilal Taymaz-Nikerel Quantitative Systems Biology for Engineering Organisms and Pathways |
| title | Quantitative Systems Biology for Engineering Organisms and Pathways |
| title_full | Quantitative Systems Biology for Engineering Organisms and Pathways |
| title_fullStr | Quantitative Systems Biology for Engineering Organisms and Pathways |
| title_full_unstemmed | Quantitative Systems Biology for Engineering Organisms and Pathways |
| title_short | Quantitative Systems Biology for Engineering Organisms and Pathways |
| title_sort | quantitative systems biology for engineering organisms and pathways |
| topic | TP248.13-248.65 TA1-2040 Metabolic Engineering Cell factories Systems Biology thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology |
| topic_facet | TP248.13-248.65 TA1-2040 Metabolic Engineering Cell factories Systems Biology thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering::TCB Biotechnology |
| url | 18216 |
| work_keys_str_mv | AT alvarorlara quantitativesystemsbiologyforengineeringorganismsandpathways AT hilaltaymaznikerel quantitativesystemsbiologyforengineeringorganismsandpathways |