Recent Development of Electrospinning for Drug Delivery
Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high...
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| Κύριοι συγγραφείς: | , , |
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| Μορφή: | Online |
| Γλώσσα: | Αγγλικά |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Θέματα: | |
| Διαθέσιμο Online: | 44867 |
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| _version_ | 1869523136245923840 |
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| author | Zelkó, Romána Lamprou, Dimitrios A. Sebe, István |
| author_browse | Lamprou, Dimitrios A. Sebe, István Zelkó, Romána |
| author_facet | Zelkó, Romána Lamprou, Dimitrios A. Sebe, István |
| author_sort | Zelkó, Romána |
| collection | Directory of Open Access Books |
| description | Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included. |
| format | Online |
| id | doab-20.500.12854ir-57765 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-577652024-03-30T23:23:07Z Recent Development of Electrospinning for Drug Delivery Zelkó, Romána Lamprou, Dimitrios A. Sebe, István R5-920 RM1-950 antibacterial activity piroxicam n/a tissue engineering biotechnology polydextrose solvent casting antibacterial drug delivery diabetic pectin nanotechnology nanocomposite hydroxypropyl methyl cellulose poorly water-soluble drug artificial red blood cells oral dosage form Lactobacillus scanning electron microscopy wound healing UV imaging wetting biocompatibility scale-up polylactide-co-polycaprolactone nanofibers growth factor drug release kinetics hydrogel differential scanning calorimetry bacterial bioreporters physical solid-state properties PCL coaxial spinning drug delivery system haemanthamine probiotics amphiphilic nanofibers wound dressings grinding scanning white light interferometry biopharmaceuticals clove essential oil viability plant-origin alkaloid oligochitosan local delivery electrospinning Lactococcus self-assembled liposomes microcapsules microfibers nanofiber in situ drug release biomedical core-sheath nanofibers processability polymeric carrier aceclofenac drying gentamicin sulfate traditional electrospinning electrospinning and electrospray fourier transform infrared spectroscopy drug release gelatin ultrasound-enhanced electrospinning 3D printing thema EDItEUR::M Medicine and Nursing Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included. 2021-02-12T01:06:01Z 2021-02-12T01:06:01Z 2020-04-07 23:07:09 2020 book 44867 9783039281411 9783039281404 https://directory.doabooks.org/handle/20.500.12854/57765 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2145 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-141-1 10.3390/books978-3-03928-141-1 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039281411 9783039281404 206 open access |
| spellingShingle | R5-920 RM1-950 antibacterial activity piroxicam n/a tissue engineering biotechnology polydextrose solvent casting antibacterial drug delivery diabetic pectin nanotechnology nanocomposite hydroxypropyl methyl cellulose poorly water-soluble drug artificial red blood cells oral dosage form Lactobacillus scanning electron microscopy wound healing UV imaging wetting biocompatibility scale-up polylactide-co-polycaprolactone nanofibers growth factor drug release kinetics hydrogel differential scanning calorimetry bacterial bioreporters physical solid-state properties PCL coaxial spinning drug delivery system haemanthamine probiotics amphiphilic nanofibers wound dressings grinding scanning white light interferometry biopharmaceuticals clove essential oil viability plant-origin alkaloid oligochitosan local delivery electrospinning Lactococcus self-assembled liposomes microcapsules microfibers nanofiber in situ drug release biomedical core-sheath nanofibers processability polymeric carrier aceclofenac drying gentamicin sulfate traditional electrospinning electrospinning and electrospray fourier transform infrared spectroscopy drug release gelatin ultrasound-enhanced electrospinning 3D printing thema EDItEUR::M Medicine and Nursing Zelkó, Romána Lamprou, Dimitrios A. Sebe, István Recent Development of Electrospinning for Drug Delivery |
| title | Recent Development of Electrospinning for Drug Delivery |
| title_full | Recent Development of Electrospinning for Drug Delivery |
| title_fullStr | Recent Development of Electrospinning for Drug Delivery |
| title_full_unstemmed | Recent Development of Electrospinning for Drug Delivery |
| title_short | Recent Development of Electrospinning for Drug Delivery |
| title_sort | recent development of electrospinning for drug delivery |
| topic | R5-920 RM1-950 antibacterial activity piroxicam n/a tissue engineering biotechnology polydextrose solvent casting antibacterial drug delivery diabetic pectin nanotechnology nanocomposite hydroxypropyl methyl cellulose poorly water-soluble drug artificial red blood cells oral dosage form Lactobacillus scanning electron microscopy wound healing UV imaging wetting biocompatibility scale-up polylactide-co-polycaprolactone nanofibers growth factor drug release kinetics hydrogel differential scanning calorimetry bacterial bioreporters physical solid-state properties PCL coaxial spinning drug delivery system haemanthamine probiotics amphiphilic nanofibers wound dressings grinding scanning white light interferometry biopharmaceuticals clove essential oil viability plant-origin alkaloid oligochitosan local delivery electrospinning Lactococcus self-assembled liposomes microcapsules microfibers nanofiber in situ drug release biomedical core-sheath nanofibers processability polymeric carrier aceclofenac drying gentamicin sulfate traditional electrospinning electrospinning and electrospray fourier transform infrared spectroscopy drug release gelatin ultrasound-enhanced electrospinning 3D printing thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RM1-950 antibacterial activity piroxicam n/a tissue engineering biotechnology polydextrose solvent casting antibacterial drug delivery diabetic pectin nanotechnology nanocomposite hydroxypropyl methyl cellulose poorly water-soluble drug artificial red blood cells oral dosage form Lactobacillus scanning electron microscopy wound healing UV imaging wetting biocompatibility scale-up polylactide-co-polycaprolactone nanofibers growth factor drug release kinetics hydrogel differential scanning calorimetry bacterial bioreporters physical solid-state properties PCL coaxial spinning drug delivery system haemanthamine probiotics amphiphilic nanofibers wound dressings grinding scanning white light interferometry biopharmaceuticals clove essential oil viability plant-origin alkaloid oligochitosan local delivery electrospinning Lactococcus self-assembled liposomes microcapsules microfibers nanofiber in situ drug release biomedical core-sheath nanofibers processability polymeric carrier aceclofenac drying gentamicin sulfate traditional electrospinning electrospinning and electrospray fourier transform infrared spectroscopy drug release gelatin ultrasound-enhanced electrospinning 3D printing thema EDItEUR::M Medicine and Nursing |
| url | 44867 |
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