Recent Progress in Solid Dispersion Technology

Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recen...

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Hovedforfatter: Kawakami, Kohsaku
Format: Online
Sprog:engelsk
Udgivet: MDPI - Multidisciplinary Digital Publishing Institute 2021
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Online adgang:42550
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author Kawakami, Kohsaku
author_browse Kawakami, Kohsaku
author_facet Kawakami, Kohsaku
author_sort Kawakami, Kohsaku
collection Directory of Open Access Books
description Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.
format Online
id doab-20.500.12854ir-57786
institution Directory of Open Access Books
language eng
publishDate 2021
publishDateRange 2021
publishDateSort 2021
publisher MDPI - Multidisciplinary Digital Publishing Institute
publisherStr MDPI - Multidisciplinary Digital Publishing Institute
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spelling doab-20.500.12854ir-577862024-04-05T12:33:10Z Recent Progress in Solid Dispersion Technology Kawakami, Kohsaku QH301-705.5 Q1-390 thermodynamic modeling molecular dynamics simulation poorly soluble drugs amorphous solid dispersions dissolution enhancement crystallization tendency continuous processing stability milling granulation thermal analysis amorphous ball milling pharmaceutical glass dissolution rebamipide poloxamer classification polyelectrolytes amorphisation self-assembly dissolution rate miscibility bioavailability solubility evaporation mesoporous polyelectrolyte excipient matrix polymer bicaludamide phase diagram Weibull dissolution model spectroscopic techniques anticancer drugs manufacturing methods nucleation molecular complex nanoaggregates enrofloxacin accelerated stability test solubility enhancement amorphous solid dispersion tadalafil process development amorphous polymeric salt Wood’s apparatus hot melt extrusion solid dispersions intrinsic dissolution rate solid dispersion interaction crystallization spray drying characterization ciprofloxacin thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD’s natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics. 2021-02-12T01:07:40Z 2021-02-12T01:07:40Z 2019-12-09 11:49:15 2019 book 42550 9783039215010 9783039215027 https://directory.doabooks.org/handle/20.500.12854/57786 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1607 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-502-7 10.3390/books978-3-03921-502-7 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039215010 9783039215027 204 open access
spellingShingle QH301-705.5
Q1-390
thermodynamic modeling
molecular dynamics simulation
poorly soluble drugs
amorphous solid dispersions
dissolution enhancement
crystallization tendency
continuous processing
stability
milling
granulation
thermal analysis
amorphous
ball milling
pharmaceutical glass
dissolution
rebamipide
poloxamer
classification
polyelectrolytes
amorphisation
self-assembly
dissolution rate
miscibility
bioavailability
solubility
evaporation
mesoporous
polyelectrolyte excipient matrix
polymer
bicaludamide
phase diagram
Weibull dissolution model
spectroscopic techniques
anticancer drugs
manufacturing methods
nucleation
molecular complex
nanoaggregates
enrofloxacin
accelerated stability test
solubility enhancement
amorphous solid dispersion
tadalafil
process development
amorphous polymeric salt
Wood’s apparatus
hot melt extrusion
solid dispersions
intrinsic dissolution rate
solid dispersion
interaction
crystallization
spray drying
characterization
ciprofloxacin
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
Kawakami, Kohsaku
Recent Progress in Solid Dispersion Technology
title Recent Progress in Solid Dispersion Technology
title_full Recent Progress in Solid Dispersion Technology
title_fullStr Recent Progress in Solid Dispersion Technology
title_full_unstemmed Recent Progress in Solid Dispersion Technology
title_short Recent Progress in Solid Dispersion Technology
title_sort recent progress in solid dispersion technology
topic QH301-705.5
Q1-390
thermodynamic modeling
molecular dynamics simulation
poorly soluble drugs
amorphous solid dispersions
dissolution enhancement
crystallization tendency
continuous processing
stability
milling
granulation
thermal analysis
amorphous
ball milling
pharmaceutical glass
dissolution
rebamipide
poloxamer
classification
polyelectrolytes
amorphisation
self-assembly
dissolution rate
miscibility
bioavailability
solubility
evaporation
mesoporous
polyelectrolyte excipient matrix
polymer
bicaludamide
phase diagram
Weibull dissolution model
spectroscopic techniques
anticancer drugs
manufacturing methods
nucleation
molecular complex
nanoaggregates
enrofloxacin
accelerated stability test
solubility enhancement
amorphous solid dispersion
tadalafil
process development
amorphous polymeric salt
Wood’s apparatus
hot melt extrusion
solid dispersions
intrinsic dissolution rate
solid dispersion
interaction
crystallization
spray drying
characterization
ciprofloxacin
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
topic_facet QH301-705.5
Q1-390
thermodynamic modeling
molecular dynamics simulation
poorly soluble drugs
amorphous solid dispersions
dissolution enhancement
crystallization tendency
continuous processing
stability
milling
granulation
thermal analysis
amorphous
ball milling
pharmaceutical glass
dissolution
rebamipide
poloxamer
classification
polyelectrolytes
amorphisation
self-assembly
dissolution rate
miscibility
bioavailability
solubility
evaporation
mesoporous
polyelectrolyte excipient matrix
polymer
bicaludamide
phase diagram
Weibull dissolution model
spectroscopic techniques
anticancer drugs
manufacturing methods
nucleation
molecular complex
nanoaggregates
enrofloxacin
accelerated stability test
solubility enhancement
amorphous solid dispersion
tadalafil
process development
amorphous polymeric salt
Wood’s apparatus
hot melt extrusion
solid dispersions
intrinsic dissolution rate
solid dispersion
interaction
crystallization
spray drying
characterization
ciprofloxacin
thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
url 42550
work_keys_str_mv AT kawakamikohsaku recentprogressinsoliddispersiontechnology