Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement
Retrotransposons are present in essentially all eukaryotic genomes and come in two basic flavors: those that are bracketed by long terminal repeats (LTRs) and share a common ancestor with retroviruses, and non-LTR retrotransposons that have a distinct lineage and remain transpositionally active in h...
Сохранить в:
| Главные авторы: | , |
|---|---|
| Формат: | Online |
| Язык: | английский |
| Опубликовано: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
|
| Предметы: | |
| Online-ссылка: | 24928 |
| Метки: |
Нет меток, Требуется 1-ая метка записи!
|
| _version_ | 1869524234108141568 |
|---|---|
| author | David J. Garfinkel (Ed.) Katarzyna J. Purzycka (Ed.) |
| author_browse | David J. Garfinkel (Ed.) Katarzyna J. Purzycka (Ed.) |
| author_facet | David J. Garfinkel (Ed.) Katarzyna J. Purzycka (Ed.) |
| author_sort | David J. Garfinkel (Ed.) |
| collection | Directory of Open Access Books |
| description | Retrotransposons are present in essentially all eukaryotic genomes and come in two basic flavors: those that are bracketed by long terminal repeats (LTRs) and share a common ancestor with retroviruses, and non-LTR retrotransposons that have a distinct lineage and remain transpositionally active in humans. Both types of retrotransposons replicate through an RNA intermediate, stably integrate into the host genome and have accumulated to a very high copy number in mammals and certain plant species. Autonomous elements produce transcripts capable of undergoing reverse transcription, and minimally encode proteins with reverse transcriptase, integrase/endonucleolytic, and nucleic acid chaperone activities. Retrotransposons are currently distinguished from viruses, since the process of retrotransposition is not infectious. However, this boundary may prove to be provisional as we learn more about these mobile genetic elements. The goal of this Special Issue of Viruses is to highlight progress in understanding the mechanism and consequences of retrotransposon movement. Several active research areas may be covered in reviews and research articles, including the roles of cellular modulators and defense systems, retrotransposon expression and replication, retrotransposon-induced mutations and their association with human diseases, and how these widely disseminated elements mold eukaryotic genomes. |
| format | Online |
| id | doab-20.500.12854ir-57787 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-577872024-04-05T12:33:00Z Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement David J. Garfinkel (Ed.) Katarzyna J. Purzycka (Ed.) QH301-705.5 Non-LTR retrotransposon Integration Human disease Endogenous retrovirus Reverse transcription Host factors Genome evolution LTR retrotransposon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Retrotransposons are present in essentially all eukaryotic genomes and come in two basic flavors: those that are bracketed by long terminal repeats (LTRs) and share a common ancestor with retroviruses, and non-LTR retrotransposons that have a distinct lineage and remain transpositionally active in humans. Both types of retrotransposons replicate through an RNA intermediate, stably integrate into the host genome and have accumulated to a very high copy number in mammals and certain plant species. Autonomous elements produce transcripts capable of undergoing reverse transcription, and minimally encode proteins with reverse transcriptase, integrase/endonucleolytic, and nucleic acid chaperone activities. Retrotransposons are currently distinguished from viruses, since the process of retrotransposition is not infectious. However, this boundary may prove to be provisional as we learn more about these mobile genetic elements. The goal of this Special Issue of Viruses is to highlight progress in understanding the mechanism and consequences of retrotransposon movement. Several active research areas may be covered in reviews and research articles, including the roles of cellular modulators and defense systems, retrotransposon expression and replication, retrotransposon-induced mutations and their association with human diseases, and how these widely disseminated elements mold eukaryotic genomes. 2021-02-12T01:07:45Z 2021-02-12T01:07:45Z 2017-12-27 09:08:55 2017 book 24928 9783038425410 9783038425403 https://directory.doabooks.org/handle/20.500.12854/57787 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International http://sci.fo/498 http://www.mdpi.com/books/pdfview/book/443 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038425410 9783038425403 VIII, 194 open access |
| spellingShingle | QH301-705.5 Non-LTR retrotransposon Integration Human disease Endogenous retrovirus Reverse transcription Host factors Genome evolution LTR retrotransposon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences David J. Garfinkel (Ed.) Katarzyna J. Purzycka (Ed.) Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement |
| title | Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement |
| title_full | Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement |
| title_fullStr | Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement |
| title_full_unstemmed | Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement |
| title_short | Recent Progress in Understanding the Mechanism and Consequences of Retrotransposon Movement |
| title_sort | recent progress in understanding the mechanism and consequences of retrotransposon movement |
| topic | QH301-705.5 Non-LTR retrotransposon Integration Human disease Endogenous retrovirus Reverse transcription Host factors Genome evolution LTR retrotransposon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Non-LTR retrotransposon Integration Human disease Endogenous retrovirus Reverse transcription Host factors Genome evolution LTR retrotransposon thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 24928 |
| work_keys_str_mv | AT davidjgarfinkeled recentprogressinunderstandingthemechanismandconsequencesofretrotransposonmovement AT katarzynajpurzyckaed recentprogressinunderstandingthemechanismandconsequencesofretrotransposonmovement |