Redox and Metabolic Circuits in Cancer
Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to ge...
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| Format: | Online |
| Jezik: | engleski |
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Frontiers Media SA
2021
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| Online pristup: | 32033 |
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| author | Salvatore Rizza Giuseppe Filomeni Andrea Rasola Danyelle M. Townsend |
| author_browse | Andrea Rasola Danyelle M. Townsend Giuseppe Filomeni Salvatore Rizza |
| author_facet | Salvatore Rizza Giuseppe Filomeni Andrea Rasola Danyelle M. Townsend |
| author_sort | Salvatore Rizza |
| collection | Directory of Open Access Books |
| description | Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint. |
| format | Online |
| id | doab-20.500.12854ir-57915 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-579152024-03-30T23:21:39Z Redox and Metabolic Circuits in Cancer Salvatore Rizza Giuseppe Filomeni Andrea Rasola Danyelle M. Townsend R5-920 RC254-282 hypoxia Mitochondria Bioenergetics Cancer Metabolism ROS S-nitrosylation Autophagy redox Warburg effect thema EDItEUR::M Medicine and Nursing Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint. 2021-02-12T01:19:29Z 2021-02-12T01:19:29Z 2019-01-23 14:53:43 2018 book 32033 16648714 9782889456352 https://directory.doabooks.org/handle/20.500.12854/57915 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/6407/redox-and-metabolic-circuits-in-cancer Frontiers Media SA 10.3389/978-2-88945-635-2 10.3389/978-2-88945-635-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456352 183 open access |
| spellingShingle | R5-920 RC254-282 hypoxia Mitochondria Bioenergetics Cancer Metabolism ROS S-nitrosylation Autophagy redox Warburg effect thema EDItEUR::M Medicine and Nursing Salvatore Rizza Giuseppe Filomeni Andrea Rasola Danyelle M. Townsend Redox and Metabolic Circuits in Cancer |
| title | Redox and Metabolic Circuits in Cancer |
| title_full | Redox and Metabolic Circuits in Cancer |
| title_fullStr | Redox and Metabolic Circuits in Cancer |
| title_full_unstemmed | Redox and Metabolic Circuits in Cancer |
| title_short | Redox and Metabolic Circuits in Cancer |
| title_sort | redox and metabolic circuits in cancer |
| topic | R5-920 RC254-282 hypoxia Mitochondria Bioenergetics Cancer Metabolism ROS S-nitrosylation Autophagy redox Warburg effect thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 hypoxia Mitochondria Bioenergetics Cancer Metabolism ROS S-nitrosylation Autophagy redox Warburg effect thema EDItEUR::M Medicine and Nursing |
| url | 32033 |
| work_keys_str_mv | AT salvatorerizza redoxandmetaboliccircuitsincancer AT giuseppefilomeni redoxandmetaboliccircuitsincancer AT andrearasola redoxandmetaboliccircuitsincancer AT danyellemtownsend redoxandmetaboliccircuitsincancer |