Redox Regulation in Skeletal Muscle Aging and Exercise
Skeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life qu...
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Frontiers Media SA
2021
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| _version_ | 1869516236419760128 |
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| author | Brian McDonagh |
| author_browse | Brian McDonagh |
| author_facet | Brian McDonagh |
| author_sort | Brian McDonagh |
| collection | Directory of Open Access Books |
| description | Skeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise. |
| format | Online |
| id | doab-20.500.12854ir-57918 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
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| spelling | doab-20.500.12854ir-579182024-03-31T22:45:06Z Redox Regulation in Skeletal Muscle Aging and Exercise Brian McDonagh QP1-981 Q1-390 Mitochondria Sternohyoid muscle uremic myopathy sphingomyelinase Muscle Fatigue sirt3 Calveolin-3 NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Skeletal muscle represents the largest organ of the human body and comprises about 40% of total body mass in humans. Even in people who ‘age well’, there is a noticeable loss of muscle strength and function that accelerates dramatically after the age of 60, a major factor in the reduction in life quality for the aging population. One of the most effective interventions to maintain muscle mass and function is through exercise. Skeletal muscle generates reactive oxygen and reactive nitrogen (ROS/RNS) species in response to muscle contractions. The concentration and species of ROS/RNS generated can depend on the age and fitness of the individual, muscle fibre type and the intensity of the muscle contractions. ROS/RNS generate unique signaling cascades that are not only essential in skeletal muscle contraction and adaptation but also play a role in a wide array of cell processes including cell proliferation, protein synthesis/degradation, immune response and antioxidant defense. ROS/RNS generated by contractions are involved in a co-ordinated local response that is tightly controlled at all levels from generation to detoxification. This collection of original articles and reviews highlights investigations that measure different aspects of the redox response of skeletal muscle to aging and exercise. 2021-02-12T01:19:46Z 2021-02-12T01:19:46Z 2017-10-13 14:57:01 2017 book 24003 16648714 9782889451968 https://directory.doabooks.org/handle/20.500.12854/57918 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Redox_Regulation_in_Skeletal_Muscle_Aging_and_Exercise/1238#nogo http://journal.frontiersin.org/researchtopic/2723/redox-regulation-in-skeletal-muscle-aging-and-exercise Frontiers Media SA 10.3389/978-2-88945-196-8 10.3389/978-2-88945-196-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889451968 101 open access |
| spellingShingle | QP1-981 Q1-390 Mitochondria Sternohyoid muscle uremic myopathy sphingomyelinase Muscle Fatigue sirt3 Calveolin-3 NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Brian McDonagh Redox Regulation in Skeletal Muscle Aging and Exercise |
| title | Redox Regulation in Skeletal Muscle Aging and Exercise |
| title_full | Redox Regulation in Skeletal Muscle Aging and Exercise |
| title_fullStr | Redox Regulation in Skeletal Muscle Aging and Exercise |
| title_full_unstemmed | Redox Regulation in Skeletal Muscle Aging and Exercise |
| title_short | Redox Regulation in Skeletal Muscle Aging and Exercise |
| title_sort | redox regulation in skeletal muscle aging and exercise |
| topic | QP1-981 Q1-390 Mitochondria Sternohyoid muscle uremic myopathy sphingomyelinase Muscle Fatigue sirt3 Calveolin-3 NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 Mitochondria Sternohyoid muscle uremic myopathy sphingomyelinase Muscle Fatigue sirt3 Calveolin-3 NADPH Oxidase thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 24003 |
| work_keys_str_mv | AT brianmcdonagh redoxregulationinskeletalmuscleagingandexercise |