Refining Prevention: Genetic and Epigenetic Contributions
Currently, most prevention efforts are framed as universal interventions. However, despite the demonstrated efficacy of many prevention programs, variability in response is the rule with some participants responding very little and others accounting for the bulk of the positive impact of the program...
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| 主要な著者: | , |
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| フォーマット: | Online |
| 言語: | 英語 |
| 出版事項: |
Frontiers Media SA
2021
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| 主題: | |
| オンライン･アクセス: | 18195 |
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| _version_ | 1869516991575883776 |
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| author | Jessica McDermott Sales Steven R.H. Beach |
| author_browse | Jessica McDermott Sales Steven R.H. Beach |
| author_facet | Jessica McDermott Sales Steven R.H. Beach |
| author_sort | Jessica McDermott Sales |
| collection | Directory of Open Access Books |
| description | Currently, most prevention efforts are framed as universal interventions. However, despite the demonstrated efficacy of many prevention programs, variability in response is the rule with some participants responding very little and others accounting for the bulk of the positive impact of the program. Better understanding the processes associated with better and worse response to prevention is a critical first step in refining and adapting existing programs, or alternatively designing new prevention programs with enhanced outcomes. Because vulnerabilities to substance use, emotional problems, risky sexual behavior and other behavioral problems are influenced by a combination of environmental, genetic, and epigenetic factors, mediated in part through psychological processes (Kreek et al., 2005; Rutter et al., 2006), the study of genetic and epigenetic vulnerability and susceptibility factors provides an important starting point for efforts to address this critical need. A growing body of research on differential genetic susceptibility indicates that efforts to enhance prevention impact may benefit from consideration of the contribution of individualgenetic differences to treatment response (Brody et al., 2013). In addition, the recent expansion of genetic research to include a focus on epigenetic change provides considerable promise for the development of indicated prevention and individually tailored prevention efforts. However, before this promise can be realized, a number of theoretical and practical challenges remain. Thus, through this special section, we provide a foundation for a new era of prevention research in which the principles of prevention science are combined with genomic science. In the current special section we bring together authors to deal with genetic and epigenetically driven processes relevant to depression, substance abuse, and sexual risk taking. Together they comment on, and provide data relevant to, assessment, research and statistical methods, The papers help to inform the development of a new generation of prevention programs that go beyond universal programs and sensitively target key processes while providing greater precision regarding prediction of population-level impact. |
| format | Online |
| id | doab-20.500.12854ir-57932 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-579322024-03-29T08:00:06Z Refining Prevention: Genetic and Epigenetic Contributions Jessica McDermott Sales Steven R.H. Beach BF1-990 Q1-390 substance use translation Genetics Mental Health prevention epigenetics bic Book Industry Communication::J Society & social sciences::JM Psychology thema EDItEUR::J Society and Social Sciences::JM Psychology Currently, most prevention efforts are framed as universal interventions. However, despite the demonstrated efficacy of many prevention programs, variability in response is the rule with some participants responding very little and others accounting for the bulk of the positive impact of the program. Better understanding the processes associated with better and worse response to prevention is a critical first step in refining and adapting existing programs, or alternatively designing new prevention programs with enhanced outcomes. Because vulnerabilities to substance use, emotional problems, risky sexual behavior and other behavioral problems are influenced by a combination of environmental, genetic, and epigenetic factors, mediated in part through psychological processes (Kreek et al., 2005; Rutter et al., 2006), the study of genetic and epigenetic vulnerability and susceptibility factors provides an important starting point for efforts to address this critical need. A growing body of research on differential genetic susceptibility indicates that efforts to enhance prevention impact may benefit from consideration of the contribution of individualgenetic differences to treatment response (Brody et al., 2013). In addition, the recent expansion of genetic research to include a focus on epigenetic change provides considerable promise for the development of indicated prevention and individually tailored prevention efforts. However, before this promise can be realized, a number of theoretical and practical challenges remain. Thus, through this special section, we provide a foundation for a new era of prevention research in which the principles of prevention science are combined with genomic science. In the current special section we bring together authors to deal with genetic and epigenetically driven processes relevant to depression, substance abuse, and sexual risk taking. Together they comment on, and provide data relevant to, assessment, research and statistical methods, The papers help to inform the development of a new generation of prevention programs that go beyond universal programs and sensitively target key processes while providing greater precision regarding prediction of population-level impact. 2021-02-12T01:21:02Z 2021-02-12T01:21:02Z 2016-01-19 14:05:46 2016 book 18195 16648714 9782889198085 https://directory.doabooks.org/handle/20.500.12854/57932 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Refining_Prevention_Genetic_and_Epigenetic_Contributions/846 http://journal.frontiersin.org/researchtopic/3348/refining-prevention-genetic-and-epigenetic-contributions Frontiers Media SA 10.3389/978-2-88919-808-5 10.3389/978-2-88919-808-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889198085 94 open access |
| spellingShingle | BF1-990 Q1-390 substance use translation Genetics Mental Health prevention epigenetics bic Book Industry Communication::J Society & social sciences::JM Psychology thema EDItEUR::J Society and Social Sciences::JM Psychology Jessica McDermott Sales Steven R.H. Beach Refining Prevention: Genetic and Epigenetic Contributions |
| title | Refining Prevention: Genetic and Epigenetic Contributions |
| title_full | Refining Prevention: Genetic and Epigenetic Contributions |
| title_fullStr | Refining Prevention: Genetic and Epigenetic Contributions |
| title_full_unstemmed | Refining Prevention: Genetic and Epigenetic Contributions |
| title_short | Refining Prevention: Genetic and Epigenetic Contributions |
| title_sort | refining prevention genetic and epigenetic contributions |
| topic | BF1-990 Q1-390 substance use translation Genetics Mental Health prevention epigenetics bic Book Industry Communication::J Society & social sciences::JM Psychology thema EDItEUR::J Society and Social Sciences::JM Psychology |
| topic_facet | BF1-990 Q1-390 substance use translation Genetics Mental Health prevention epigenetics bic Book Industry Communication::J Society & social sciences::JM Psychology thema EDItEUR::J Society and Social Sciences::JM Psychology |
| url | 18195 |
| work_keys_str_mv | AT jessicamcdermottsales refiningpreventiongeneticandepigeneticcontributions AT stevenrhbeach refiningpreventiongeneticandepigeneticcontributions |