The regulated secretory pathway in neuroendocrine cells
The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytos...
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| Main Authors: | , |
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| פורמט: | Online |
| שפה: | אנגלית |
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Frontiers Media SA
2021
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| נושאים: | |
| גישה מקוונת: | 17657 |
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| _version_ | 1869523599882190848 |
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| author | Rafael Vazquez-Martinez Stephane Gasman |
| author_browse | Rafael Vazquez-Martinez Stephane Gasman |
| author_facet | Rafael Vazquez-Martinez Stephane Gasman |
| author_sort | Rafael Vazquez-Martinez |
| collection | Directory of Open Access Books |
| description | The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides. |
| format | Online |
| id | doab-20.500.12854ir-58030 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-580302022-01-31T13:28:54Z The regulated secretory pathway in neuroendocrine cells Rafael Vazquez-Martinez Stephane Gasman RC648-665 R5-920 RC321-571 Q1-390 Neuroendocrine Cells regulated exocytosis Endocytosis secretion large dense core vesicles Membrane trafficking super-resolution microscopy The regulated secretory pathway is a hallmark of neuroendocrine cells. This process comprises many sequential steps, which include ER-associated protein synthesis, post-translational modification of proteins in the Golgi complex, sorting and packing of secretory proteins into carrier granules, cytoskeleton-based granule transport towards the plasma membrane and tethering, docking and fusion of granules with specialized releasing zones. Each stage is subjected to a rigorous regulation by a plethora of factors that function in a spatially and temporarily coordinated fashion. Much effort has been devoted to characterize the precise role of the regulatory proteins participating in the different steps of this process and to identify new factors in order to obtain a unifying picture of the secretory pathway. In spite of this and given the enormous complexity of the process, certain stages are not fully understood yet and many players remain to be identified. The aim of this Research Topic is to gather review articles and original research papers on the molecular mechanisms that govern and ensure the correct release of neuropeptides. 2021-02-12T01:30:11Z 2021-02-12T01:30:11Z 2015-11-16 15:44:59 2014 book 17657 16648714 9782889192465 https://directory.doabooks.org/handle/20.500.12854/58030 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_regulated_secretory_pathway_in_neuroendocrine_cells/295#nogo http://journal.frontiersin.org/researchtopic/956/the-regulated-secretory-pathway-in-neuroendocrine-cells Frontiers Media SA 10.3389/978-2-88919-246-5 10.3389/978-2-88919-246-5 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192465 157 open access |
| spellingShingle | RC648-665 R5-920 RC321-571 Q1-390 Neuroendocrine Cells regulated exocytosis Endocytosis secretion large dense core vesicles Membrane trafficking super-resolution microscopy Rafael Vazquez-Martinez Stephane Gasman The regulated secretory pathway in neuroendocrine cells |
| title | The regulated secretory pathway in neuroendocrine cells |
| title_full | The regulated secretory pathway in neuroendocrine cells |
| title_fullStr | The regulated secretory pathway in neuroendocrine cells |
| title_full_unstemmed | The regulated secretory pathway in neuroendocrine cells |
| title_short | The regulated secretory pathway in neuroendocrine cells |
| title_sort | regulated secretory pathway in neuroendocrine cells |
| topic | RC648-665 R5-920 RC321-571 Q1-390 Neuroendocrine Cells regulated exocytosis Endocytosis secretion large dense core vesicles Membrane trafficking super-resolution microscopy |
| topic_facet | RC648-665 R5-920 RC321-571 Q1-390 Neuroendocrine Cells regulated exocytosis Endocytosis secretion large dense core vesicles Membrane trafficking super-resolution microscopy |
| url | 17657 |
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