Regulation of Chemokine- Receptor Interactions and Functions
A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the d...
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| Format: | Online |
| Language: | English |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | 26227 |
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| _version_ | 1869518879347179520 |
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| author | Martin J. Stone (Ed.) |
| author_browse | Martin J. Stone (Ed.) |
| author_facet | Martin J. Stone (Ed.) |
| author_sort | Martin J. Stone (Ed.) |
| collection | Directory of Open Access Books |
| description | A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms; control of expression levels; ligand internalization via functional or decoy receptors; intrinsic selectivity of chemokine-receptor binding; hetero- or homo-oligomerization of chemokines or of receptors; alternative signalling pathways; interaction of chemokines with glycosaminoglycans; post-translational modifications; and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated. |
| format | Online |
| id | doab-20.500.12854ir-58036 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-580362024-04-05T17:30:43Z Regulation of Chemokine- Receptor Interactions and Functions Martin J. Stone (Ed.) QD415-436 chemokine expression signaling regulation oligomerization binding inhibition post-translational modification glycosaminoglycan chemokine receptor thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry A hallmark of inflammation is the accumulation of leukocytes, which can serve to remove pathogens and necrotic tissue, but may also damage healthy tissue and exacerbate the inflammatory response. Our understanding of leukocyte recruitment in inflammation was revolutionized in the late 1980s by the discovery of chemokines (chemotactic cytokines), a family of small, secreted proteins that induce migration of selective subsets of leukocytes. Shortly afterwards, chemokines were found to exert their functions through the now familiar chemokine receptors, members of the G protein-coupled receptor superfamily. As their physiological and pathological functions were elucidated, chemokine receptors have become popular targets for drug development in inflammatory diseases as well as cancer metastasis and HIV infection. Extensive research has revealed that the functions of chemokines and their receptors are regulated at numerous levels, including: genetic mutations/polymorphisms; control of expression levels; ligand internalization via functional or decoy receptors; intrinsic selectivity of chemokine-receptor binding; hetero- or homo-oligomerization of chemokines or of receptors; alternative signalling pathways; interaction of chemokines with glycosaminoglycans; post-translational modifications; and binding to pathogen-derived inhibitors. This Special Issue of IJMS focused on the natural and pharmacological mechanisms by which the activities of chemokines and their receptors can be regulated. 2021-02-12T01:30:45Z 2021-02-12T01:30:45Z 2018-03-26 15:44:06 2018 book 26227 9783038427285 9783038427278 https://directory.doabooks.org/handle/20.500.12854/58036 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://sci.fo/4mm http://www.mdpi.com/books/pdfview/book/566 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038427285 9783038427278 228 open access |
| spellingShingle | QD415-436 chemokine expression signaling regulation oligomerization binding inhibition post-translational modification glycosaminoglycan chemokine receptor thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry Martin J. Stone (Ed.) Regulation of Chemokine- Receptor Interactions and Functions |
| title | Regulation of Chemokine- Receptor Interactions and Functions |
| title_full | Regulation of Chemokine- Receptor Interactions and Functions |
| title_fullStr | Regulation of Chemokine- Receptor Interactions and Functions |
| title_full_unstemmed | Regulation of Chemokine- Receptor Interactions and Functions |
| title_short | Regulation of Chemokine- Receptor Interactions and Functions |
| title_sort | regulation of chemokine receptor interactions and functions |
| topic | QD415-436 chemokine expression signaling regulation oligomerization binding inhibition post-translational modification glycosaminoglycan chemokine receptor thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| topic_facet | QD415-436 chemokine expression signaling regulation oligomerization binding inhibition post-translational modification glycosaminoglycan chemokine receptor thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSB Biochemistry |
| url | 26227 |
| work_keys_str_mv | AT martinjstoneed regulationofchemokinereceptorinteractionsandfunctions |