Regulation of red cell life-span, erythropoiesis, senescence and clearance
Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell l...
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
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Frontiers Media SA
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 18678 |
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| _version_ | 1869524512695910400 |
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| author | Anna Bogdanova Lars Kaestner |
| author_browse | Anna Bogdanova Lars Kaestner |
| author_facet | Anna Bogdanova Lars Kaestner |
| author_sort | Anna Bogdanova |
| collection | Directory of Open Access Books |
| description | Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives. |
| format | Online |
| id | doab-20.500.12854ir-58040 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-580402024-03-31T22:45:12Z Regulation of red cell life-span, erythropoiesis, senescence and clearance Anna Bogdanova Lars Kaestner QP1-981 QH301-705.5 Q1-390 QC1-999 Erythropoiesis senescence neocytolysis blood storage Clearance Vesiculation erythrocyte thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives. 2021-02-12T01:31:09Z 2021-02-12T01:31:09Z 2016-03-10 08:14:32 2014 book 18678 16648714 9782889193486 https://directory.doabooks.org/handle/20.500.12854/58040 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Regulation_of_red_cell_life-span_erythropoiesis_senescence_and_clearance/383 http://journal.frontiersin.org/researchtopic/1656/regulation-of-red-cell-life-span-erythropoiesis-senescence-and-clearance Frontiers Media SA 10.3389/978-2-88919-348-6 10.3389/978-2-88919-348-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889193486 117 open access |
| spellingShingle | QP1-981 QH301-705.5 Q1-390 QC1-999 Erythropoiesis senescence neocytolysis blood storage Clearance Vesiculation erythrocyte thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Anna Bogdanova Lars Kaestner Regulation of red cell life-span, erythropoiesis, senescence and clearance |
| title | Regulation of red cell life-span, erythropoiesis, senescence and clearance |
| title_full | Regulation of red cell life-span, erythropoiesis, senescence and clearance |
| title_fullStr | Regulation of red cell life-span, erythropoiesis, senescence and clearance |
| title_full_unstemmed | Regulation of red cell life-span, erythropoiesis, senescence and clearance |
| title_short | Regulation of red cell life-span, erythropoiesis, senescence and clearance |
| title_sort | regulation of red cell life span erythropoiesis senescence and clearance |
| topic | QP1-981 QH301-705.5 Q1-390 QC1-999 Erythropoiesis senescence neocytolysis blood storage Clearance Vesiculation erythrocyte thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 QH301-705.5 Q1-390 QC1-999 Erythropoiesis senescence neocytolysis blood storage Clearance Vesiculation erythrocyte thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 18678 |
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