Ribosome Inactivating Toxins
Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apopto...
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| Asıl Yazarlar: | , |
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| Materyal Türü: | Online |
| Dil: | İngilizce |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Konular: | |
| Online Erişim: | 31740 |
| Etiketler: |
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| _version_ | 1869514905128796160 |
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| author | Daniel Gillet (Ed.) Julien Barbier (Ed.) |
| author_browse | Daniel Gillet (Ed.) Julien Barbier (Ed.) |
| author_facet | Daniel Gillet (Ed.) Julien Barbier (Ed.) |
| author_sort | Daniel Gillet (Ed.) |
| collection | Directory of Open Access Books |
| description | Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses. This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs. |
| format | Online |
| id | doab-20.500.12854ir-58457 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-584572024-03-30T23:21:40Z Ribosome Inactivating Toxins Daniel Gillet (Ed.) Julien Barbier (Ed.) R5-920 RM1-950 RA1190-1270 toxin Shiga toxin ricin Ribosome inactivating protein thema EDItEUR::M Medicine and Nursing Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses. This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs. 2021-02-12T02:17:10Z 2021-02-12T02:17:10Z 2019-01-17 10:21:23 2019 book 31740 9783038972495 9783038972488 https://directory.doabooks.org/handle/20.500.12854/58457 eng image/jpeg Attribution-NonCommercial-NoDerivatives 4.0 International https://www.mdpi.com/books/pdfview/book/1095 https://play.google.com/books/publish/a/14935057684283403269#details/ISBN:9783038972488 https://www.mdpi.com/books/pdfview/book/1095 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03897-249-5 10.3390/books978-3-03897-249-5 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038972495 9783038972488 329 open access |
| spellingShingle | R5-920 RM1-950 RA1190-1270 toxin Shiga toxin ricin Ribosome inactivating protein thema EDItEUR::M Medicine and Nursing Daniel Gillet (Ed.) Julien Barbier (Ed.) Ribosome Inactivating Toxins |
| title | Ribosome Inactivating Toxins |
| title_full | Ribosome Inactivating Toxins |
| title_fullStr | Ribosome Inactivating Toxins |
| title_full_unstemmed | Ribosome Inactivating Toxins |
| title_short | Ribosome Inactivating Toxins |
| title_sort | ribosome inactivating toxins |
| topic | R5-920 RM1-950 RA1190-1270 toxin Shiga toxin ricin Ribosome inactivating protein thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RM1-950 RA1190-1270 toxin Shiga toxin ricin Ribosome inactivating protein thema EDItEUR::M Medicine and Nursing |
| url | 31740 |
| work_keys_str_mv | AT danielgilleted ribosomeinactivatingtoxins AT julienbarbiered ribosomeinactivatingtoxins |