Role of DNA Methyltransferases in the Epigenome
DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generati...
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| Natura: | Online |
| Lingua: | inglese |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Accesso online: | 44783 |
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| _version_ | 1869515116108578816 |
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| author | Jeltsch, Albert Gowher, Humaira |
| author_browse | Gowher, Humaira Jeltsch, Albert |
| author_facet | Jeltsch, Albert Gowher, Humaira |
| author_sort | Jeltsch, Albert |
| collection | Directory of Open Access Books |
| description | DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors |
| format | Online |
| id | doab-20.500.12854ir-58578 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-585782024-04-05T12:31:49Z Role of DNA Methyltransferases in the Epigenome Jeltsch, Albert Gowher, Humaira QH301-705.5 Q1-390 DNMTs n/a histone modification TBRS DNA methyltransferases autoinhibition epigenetics DNMT cell identity embryogenesis dwarfism DNMT3B germ cells HSAN1E USP7 DNMT3A DNA methyltransferase gene expression DNMT1 de novo DNA methylation DNA methyltransferase structure UHRF1 DNA methyltransferase mechanism allosteric regulation rare diseases DNA Methylation maintenance DNA methylation DNA methylation ADCA-DN PCC/PGL ubiquitination TETs DNA methyltransferase function molecular epigenetics DNA methyltransferase regulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors 2021-02-12T02:27:24Z 2021-02-12T02:27:24Z 2020-04-07 23:07:08 2020 book 44783 9783039280216 9783039280209 https://directory.doabooks.org/handle/20.500.12854/58578 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2060 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-021-6 10.3390/books978-3-03928-021-6 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039280216 9783039280209 150 open access |
| spellingShingle | QH301-705.5 Q1-390 DNMTs n/a histone modification TBRS DNA methyltransferases autoinhibition epigenetics DNMT cell identity embryogenesis dwarfism DNMT3B germ cells HSAN1E USP7 DNMT3A DNA methyltransferase gene expression DNMT1 de novo DNA methylation DNA methyltransferase structure UHRF1 DNA methyltransferase mechanism allosteric regulation rare diseases DNA Methylation maintenance DNA methylation DNA methylation ADCA-DN PCC/PGL ubiquitination TETs DNA methyltransferase function molecular epigenetics DNA methyltransferase regulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Jeltsch, Albert Gowher, Humaira Role of DNA Methyltransferases in the Epigenome |
| title | Role of DNA Methyltransferases in the Epigenome |
| title_full | Role of DNA Methyltransferases in the Epigenome |
| title_fullStr | Role of DNA Methyltransferases in the Epigenome |
| title_full_unstemmed | Role of DNA Methyltransferases in the Epigenome |
| title_short | Role of DNA Methyltransferases in the Epigenome |
| title_sort | role of dna methyltransferases in the epigenome |
| topic | QH301-705.5 Q1-390 DNMTs n/a histone modification TBRS DNA methyltransferases autoinhibition epigenetics DNMT cell identity embryogenesis dwarfism DNMT3B germ cells HSAN1E USP7 DNMT3A DNA methyltransferase gene expression DNMT1 de novo DNA methylation DNA methyltransferase structure UHRF1 DNA methyltransferase mechanism allosteric regulation rare diseases DNA Methylation maintenance DNA methylation DNA methylation ADCA-DN PCC/PGL ubiquitination TETs DNA methyltransferase function molecular epigenetics DNA methyltransferase regulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 DNMTs n/a histone modification TBRS DNA methyltransferases autoinhibition epigenetics DNMT cell identity embryogenesis dwarfism DNMT3B germ cells HSAN1E USP7 DNMT3A DNA methyltransferase gene expression DNMT1 de novo DNA methylation DNA methyltransferase structure UHRF1 DNA methyltransferase mechanism allosteric regulation rare diseases DNA Methylation maintenance DNA methylation DNA methylation ADCA-DN PCC/PGL ubiquitination TETs DNA methyltransferase function molecular epigenetics DNA methyltransferase regulation thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 44783 |
| work_keys_str_mv | AT jeltschalbert roleofdnamethyltransferasesintheepigenome AT gowherhumaira roleofdnamethyltransferasesintheepigenome |