The Role of Glia in Plasticity and Behavior
Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in inve...
Na minha lista:
| Principais autores: | , |
|---|---|
| Formato: | Online |
| Idioma: | inglês |
| Publicado em: |
Frontiers Media SA
2021
|
| Assuntos: | |
| Acesso em linha: | 18819 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|
| _version_ | 1869515144324710400 |
|---|---|
| author | Tycho Hoogland Vladimir Parpura |
| author_browse | Tycho Hoogland Vladimir Parpura |
| author_facet | Tycho Hoogland Vladimir Parpura |
| author_sort | Tycho Hoogland |
| collection | Directory of Open Access Books |
| description | Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function. |
| format | Online |
| id | doab-20.500.12854ir-58581 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-585812024-04-05T12:35:28Z The Role of Glia in Plasticity and Behavior Tycho Hoogland Vladimir Parpura RC321-571 Q1-390 Cerebellum C. elegans Astrocytes DREADD Cortex plasticity Gq Behavior glia Hippocampus thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function. 2021-02-12T02:27:34Z 2021-02-12T02:27:34Z 2016-04-07 11:22:02 2015 book 18819 16648714 9782889196906 https://directory.doabooks.org/handle/20.500.12854/58581 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/The_Role_of_Glia_in_Plasticity_and_Behavior/756 http://journal.frontiersin.org/researchtopic/2249/the-role-of-glia-in-plasticity-and-behavior Frontiers Media SA 10.3389/978-2-88919-690-6 10.3389/978-2-88919-690-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196906 104 open access |
| spellingShingle | RC321-571 Q1-390 Cerebellum C. elegans Astrocytes DREADD Cortex plasticity Gq Behavior glia Hippocampus thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Tycho Hoogland Vladimir Parpura The Role of Glia in Plasticity and Behavior |
| title | The Role of Glia in Plasticity and Behavior |
| title_full | The Role of Glia in Plasticity and Behavior |
| title_fullStr | The Role of Glia in Plasticity and Behavior |
| title_full_unstemmed | The Role of Glia in Plasticity and Behavior |
| title_short | The Role of Glia in Plasticity and Behavior |
| title_sort | role of glia in plasticity and behavior |
| topic | RC321-571 Q1-390 Cerebellum C. elegans Astrocytes DREADD Cortex plasticity Gq Behavior glia Hippocampus thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Cerebellum C. elegans Astrocytes DREADD Cortex plasticity Gq Behavior glia Hippocampus thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 18819 |
| work_keys_str_mv | AT tychohoogland theroleofgliainplasticityandbehavior AT vladimirparpura theroleofgliainplasticityandbehavior AT tychohoogland roleofgliainplasticityandbehavior AT vladimirparpura roleofgliainplasticityandbehavior |