Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition
Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, st...
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Frontiers Media SA
2021
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| Sarrera elektronikoa: | 31902 |
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| author | Michel Kranendonk Wayne L. Backes Ulrich M. Zanger Amit V. Pandey Colin J. Henderson Yuji Ishii |
| author_browse | Amit V. Pandey Colin J. Henderson Michel Kranendonk Ulrich M. Zanger Wayne L. Backes Yuji Ishii |
| author_facet | Michel Kranendonk Wayne L. Backes Ulrich M. Zanger Amit V. Pandey Colin J. Henderson Yuji Ishii |
| author_sort | Michel Kranendonk |
| collection | Directory of Open Access Books |
| description | Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms. |
| format | Online |
| id | doab-20.500.12854ir-58604 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-586042024-04-01T14:14:55Z Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition Michel Kranendonk Wayne L. Backes Ulrich M. Zanger Amit V. Pandey Colin J. Henderson Yuji Ishii RM1-950 Q1-390 POR Pharmacogenetics UGT Biocatalysis UDP-glucuronosyltransferase Cytochrome P450 Drug metabolism Membrane-associated progesterone receptor PXR Steroids thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Genetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks. The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. Authors may submit original articles, reviews and opinion or hypothesis papers dealing with the role of protein-protein interactions in health and disease. Potential topics include, but are not limited to: • Role of protein-protein interactions in xenobiotic metabolism by cytochrome P450s and other drug metabolism enzymes. • Role of classical and novel interaction partners for cytochrome P450-dependent metabolism which may include interactions with redox partners, interactions with other P450 enzymes to form P450 dimers/multimers, P450-UGT interactions and proteins involved in posttranslational modification of P450s. • Effect of genetic variations (mutations and polymorphisms) on metabolism affected by protein-protein interactions. • Structural implications of mutations and polymorphisms on protein-protein interactions. • Functional characterization of protein-protein interactions. • Analysis of protein-protein interaction networks in health and disease. • Regulatory mechanisms governing metabolic processes based on protein-protein interactions. • Experimental approaches for identification of new protein-protein interactions including changes caused by mutations and polymorphisms. 2021-02-12T02:29:01Z 2021-02-12T02:29:01Z 2019-01-23 14:53:42 2018 book 31902 16648714 9782889454914 https://directory.doabooks.org/handle/20.500.12854/58604 eng Frontiers Research Topics application/octet-stream Attribution 4.0 International https://www.frontiersin.org/research-topics/4658/role-of-protein-protein-interactions-in-metabolism-genetics-structure-function Frontiers Media SA 10.3389/978-2-88945-491-4 10.3389/978-2-88945-491-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454914 152 open access |
| spellingShingle | RM1-950 Q1-390 POR Pharmacogenetics UGT Biocatalysis UDP-glucuronosyltransferase Cytochrome P450 Drug metabolism Membrane-associated progesterone receptor PXR Steroids thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Michel Kranendonk Wayne L. Backes Ulrich M. Zanger Amit V. Pandey Colin J. Henderson Yuji Ishii Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition |
| title | Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition |
| title_full | Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition |
| title_fullStr | Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition |
| title_full_unstemmed | Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition |
| title_short | Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function, 2nd Edition |
| title_sort | role of protein protein interactions in metabolism genetics structure function 2nd edition |
| topic | RM1-950 Q1-390 POR Pharmacogenetics UGT Biocatalysis UDP-glucuronosyltransferase Cytochrome P450 Drug metabolism Membrane-associated progesterone receptor PXR Steroids thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 Q1-390 POR Pharmacogenetics UGT Biocatalysis UDP-glucuronosyltransferase Cytochrome P450 Drug metabolism Membrane-associated progesterone receptor PXR Steroids thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 31902 |
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