Roles and Functions of ROS and RNS in Cellular Physiology and Pathology
Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and...
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
| প্রকাশিত: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 46029 |
| ট্যাগগুলো: |
কোনো ট্যাগ নেই, প্রথমজন হিসাবে ট্যাগ করুন!
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| _version_ | 1869529236614676480 |
|---|---|
| author | Zarkovic, Neven |
| author_browse | Zarkovic, Neven |
| author_facet | Zarkovic, Neven |
| author_sort | Zarkovic, Neven |
| collection | Directory of Open Access Books |
| description | Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments. |
| format | Online |
| id | doab-20.500.12854ir-58616 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-586162024-03-31T13:10:06Z Roles and Functions of ROS and RNS in Cellular Physiology and Pathology Zarkovic, Neven R5-920 RB1-214 toxicity toll-like receptors acrolein hydroxyapatite-based biomaterials LC-MS/MS blood–brain barrier NADPH-oxidase human neuroblastoma SH-SY5Y cells NRF2-NQO1 axis granulocytes free radicals antioxidant plaque vulnerability bEnd.3 relaxation Ca2+ keratinocytes oxidative metabolism of the cells lipid peroxidation intermittent hypoxia osteoblast growth UV radiation ROS bEnd5 cyclopurines NF?B glucose deprivation antimicrobial endothelial cells 4-hydroxynonenal (4-HNE) histamine glutamine deprivation optical coherence tomography antioxidants DNA damage glutathione NQO1 transcript variants xeroderma pigmentosum cancer cells VAS2870 reactive oxygen species (ROS) TP53 mutation DNA and RNA polymerases viability oxidative burst macrophages inflammation Nrf2 von Willebrand factor reactive oxygen species growth control intracellular signaling MFN2 nuclear factor erythroid 2–related factor 2 fusion/fission IMR-90 calcium proliferation mitochondria pathophysiology of oxidative stress redox balance 4-hydroxynonenal cannabidiol oxidative homeostasis rs1800566 neuronal cell death heme-oxygenase-1 vitamins cell signaling TRPM2 channel aorta cancer growth cancer regression oxidative stress nucleotide excision repair thema EDItEUR::M Medicine and Nursing Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and reactive nitrogen species (ROS and RNS) were identified as the key players initiating, mediating, and regulating the cellular and biochemical complexity of oxidative stress either as physiological (acting pro-hormetic) or as pathogenic (causing destructive vicious circle) process. The papers published in this particular Special Issue of the Cells demonstrate the impressive pathophysiological relevance of ROS and RNS in a range of contexts, including the relevance of second messengers of free radicals like 4-hydroxynonenal, allowing us to assume that even more detailed mechanisms of their positive and negative effects lie in wait, and should assist in better monitoring of the major modern diseases and the development of advanced integrative biomedicine treatments. 2021-02-12T02:29:50Z 2021-02-12T02:29:50Z 2020-06-09 16:38:57 2020 book 46029 9783039287833 9783039287826 https://directory.doabooks.org/handle/20.500.12854/58616 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/2222 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03928-783-3 10.3390/books978-3-03928-783-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039287833 9783039287826 230 open access |
| spellingShingle | R5-920 RB1-214 toxicity toll-like receptors acrolein hydroxyapatite-based biomaterials LC-MS/MS blood–brain barrier NADPH-oxidase human neuroblastoma SH-SY5Y cells NRF2-NQO1 axis granulocytes free radicals antioxidant plaque vulnerability bEnd.3 relaxation Ca2+ keratinocytes oxidative metabolism of the cells lipid peroxidation intermittent hypoxia osteoblast growth UV radiation ROS bEnd5 cyclopurines NF?B glucose deprivation antimicrobial endothelial cells 4-hydroxynonenal (4-HNE) histamine glutamine deprivation optical coherence tomography antioxidants DNA damage glutathione NQO1 transcript variants xeroderma pigmentosum cancer cells VAS2870 reactive oxygen species (ROS) TP53 mutation DNA and RNA polymerases viability oxidative burst macrophages inflammation Nrf2 von Willebrand factor reactive oxygen species growth control intracellular signaling MFN2 nuclear factor erythroid 2–related factor 2 fusion/fission IMR-90 calcium proliferation mitochondria pathophysiology of oxidative stress redox balance 4-hydroxynonenal cannabidiol oxidative homeostasis rs1800566 neuronal cell death heme-oxygenase-1 vitamins cell signaling TRPM2 channel aorta cancer growth cancer regression oxidative stress nucleotide excision repair thema EDItEUR::M Medicine and Nursing Zarkovic, Neven Roles and Functions of ROS and RNS in Cellular Physiology and Pathology |
| title | Roles and Functions of ROS and RNS in Cellular Physiology and Pathology |
| title_full | Roles and Functions of ROS and RNS in Cellular Physiology and Pathology |
| title_fullStr | Roles and Functions of ROS and RNS in Cellular Physiology and Pathology |
| title_full_unstemmed | Roles and Functions of ROS and RNS in Cellular Physiology and Pathology |
| title_short | Roles and Functions of ROS and RNS in Cellular Physiology and Pathology |
| title_sort | roles and functions of ros and rns in cellular physiology and pathology |
| topic | R5-920 RB1-214 toxicity toll-like receptors acrolein hydroxyapatite-based biomaterials LC-MS/MS blood–brain barrier NADPH-oxidase human neuroblastoma SH-SY5Y cells NRF2-NQO1 axis granulocytes free radicals antioxidant plaque vulnerability bEnd.3 relaxation Ca2+ keratinocytes oxidative metabolism of the cells lipid peroxidation intermittent hypoxia osteoblast growth UV radiation ROS bEnd5 cyclopurines NF?B glucose deprivation antimicrobial endothelial cells 4-hydroxynonenal (4-HNE) histamine glutamine deprivation optical coherence tomography antioxidants DNA damage glutathione NQO1 transcript variants xeroderma pigmentosum cancer cells VAS2870 reactive oxygen species (ROS) TP53 mutation DNA and RNA polymerases viability oxidative burst macrophages inflammation Nrf2 von Willebrand factor reactive oxygen species growth control intracellular signaling MFN2 nuclear factor erythroid 2–related factor 2 fusion/fission IMR-90 calcium proliferation mitochondria pathophysiology of oxidative stress redox balance 4-hydroxynonenal cannabidiol oxidative homeostasis rs1800566 neuronal cell death heme-oxygenase-1 vitamins cell signaling TRPM2 channel aorta cancer growth cancer regression oxidative stress nucleotide excision repair thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RB1-214 toxicity toll-like receptors acrolein hydroxyapatite-based biomaterials LC-MS/MS blood–brain barrier NADPH-oxidase human neuroblastoma SH-SY5Y cells NRF2-NQO1 axis granulocytes free radicals antioxidant plaque vulnerability bEnd.3 relaxation Ca2+ keratinocytes oxidative metabolism of the cells lipid peroxidation intermittent hypoxia osteoblast growth UV radiation ROS bEnd5 cyclopurines NF?B glucose deprivation antimicrobial endothelial cells 4-hydroxynonenal (4-HNE) histamine glutamine deprivation optical coherence tomography antioxidants DNA damage glutathione NQO1 transcript variants xeroderma pigmentosum cancer cells VAS2870 reactive oxygen species (ROS) TP53 mutation DNA and RNA polymerases viability oxidative burst macrophages inflammation Nrf2 von Willebrand factor reactive oxygen species growth control intracellular signaling MFN2 nuclear factor erythroid 2–related factor 2 fusion/fission IMR-90 calcium proliferation mitochondria pathophysiology of oxidative stress redox balance 4-hydroxynonenal cannabidiol oxidative homeostasis rs1800566 neuronal cell death heme-oxygenase-1 vitamins cell signaling TRPM2 channel aorta cancer growth cancer regression oxidative stress nucleotide excision repair thema EDItEUR::M Medicine and Nursing |
| url | 46029 |
| work_keys_str_mv | AT zarkovicneven rolesandfunctionsofrosandrnsincellularphysiologyandpathology |