Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of...

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Autors principals:	Stefano Morotti, Eleonora Grandi, Esther Pueyo, Blanca Rodriguez
Format:	Online
Idioma:	anglès
Publicat:	Frontiers Media SA 2021
Matèries:	QP1-981 Q1-390 cardiotoxicity cardiac electrophysiology. drug-induced arrhythmia QT interval prolongation multi-scale modeling thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
Accés en línia:	31949
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