Schizophrenia: A Consequence of Gene-Environment Interactions?
Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic a...
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| المؤلفون الرئيسيون: | , |
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| التنسيق: | Online |
| اللغة: | الإنجليزية |
| منشور في: |
Frontiers Media SA
2021
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| الموضوعات: | |
| الوصول للمادة أونلاين: | 17827 |
| الوسوم: |
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| _version_ | 1869524868853137408 |
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| author | Jonathon C Arnold Tim Karl |
| author_browse | Jonathon C Arnold Tim Karl |
| author_facet | Jonathon C Arnold Tim Karl |
| author_sort | Jonathon C Arnold |
| collection | Directory of Open Access Books |
| description | Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems. |
| format | Online |
| id | doab-20.500.12854ir-58945 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-589452024-04-05T17:30:55Z Schizophrenia: A Consequence of Gene-Environment Interactions? Jonathon C Arnold Tim Karl RC321-571 Q1-390 environment gene GxE Interaction two hit hypothesis Schizophrenia animal model thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Schizophrenia is a multi-factorial disease characterized by a high heritability and environmental risk factors (e.g. stress and cannabis use). In recent years, an increasing number of researchers worldwide have started investigating the ‘two-hit hypothesis’ of schizophrenia predicting that genetic and environmental risk factors interactively cause the development of the disorder. This work is starting to produce valuable new animal models and reveal novel insights into the pathophysiology of schizophrenia. Eventually, it might help advance studies of the molecular pathways involved in this mental disorder and propose more specific molecular medicine. However, the complexity of this multi-factorial line of research has also caused difficulties in data interpretation and comparison. Our research topic is intended to cover past and current directions in research dedicated to the understanding and measurement of gene-environment interactions (GxE) in schizophrenia, the neurobiological and behavioural consequences of such interactions as well as the challenges and limitations one encounters when working on complex aetiological systems. 2021-02-12T02:58:10Z 2021-02-12T02:58:10Z 2015-12-10 11:59:06 2015 book 17827 16648714 9782889195312 https://directory.doabooks.org/handle/20.500.12854/58945 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Schizophrenia_A_Consequence_of_Gene-Environment_Interactions_/572 http://journal.frontiersin.org/researchtopic/1089/schizophrenia-a-consequence-of-gene-environment-interactions Frontiers Media SA 10.3389/978-2-88919-531-2 10.3389/978-2-88919-531-2 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889195312 126 open access |
| spellingShingle | RC321-571 Q1-390 environment gene GxE Interaction two hit hypothesis Schizophrenia animal model thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Jonathon C Arnold Tim Karl Schizophrenia: A Consequence of Gene-Environment Interactions? |
| title | Schizophrenia: A Consequence of Gene-Environment Interactions? |
| title_full | Schizophrenia: A Consequence of Gene-Environment Interactions? |
| title_fullStr | Schizophrenia: A Consequence of Gene-Environment Interactions? |
| title_full_unstemmed | Schizophrenia: A Consequence of Gene-Environment Interactions? |
| title_short | Schizophrenia: A Consequence of Gene-Environment Interactions? |
| title_sort | schizophrenia a consequence of gene environment interactions |
| topic | RC321-571 Q1-390 environment gene GxE Interaction two hit hypothesis Schizophrenia animal model thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 environment gene GxE Interaction two hit hypothesis Schizophrenia animal model thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 17827 |
| work_keys_str_mv | AT jonathoncarnold schizophreniaaconsequenceofgeneenvironmentinteractions AT timkarl schizophreniaaconsequenceofgeneenvironmentinteractions |