The Search for Biological Active Agent(s) From Actinobacteria
There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natu...
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| Fformat: | Online |
| Iaith: | Saesneg |
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Frontiers Media SA
2021
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| Mynediad Ar-lein: | 31977 |
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Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!
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| _version_ | 1869525857465270272 |
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| author | Learn-Han Lee Kok-Gan Chan Bey-Hing Goh Elizabeth M. H. Wellington Jem Stach |
| author_browse | Bey-Hing Goh Elizabeth M. H. Wellington Jem Stach Kok-Gan Chan Learn-Han Lee |
| author_facet | Learn-Han Lee Kok-Gan Chan Bey-Hing Goh Elizabeth M. H. Wellington Jem Stach |
| author_sort | Learn-Han Lee |
| collection | Directory of Open Access Books |
| description | There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. </p><p> </p><p>Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar. |
| format | Online |
| id | doab-20.500.12854ir-59061 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-590612024-04-05T17:31:04Z The Search for Biological Active Agent(s) From Actinobacteria Learn-Han Lee Kok-Gan Chan Bey-Hing Goh Elizabeth M. H. Wellington Jem Stach QR1-502 Q1-390 actinobacteria terrestrial drug discovery next generation Streptomyces marine bioactive thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. </p><p> </p><p>Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar. 2021-02-12T03:09:09Z 2021-02-12T03:09:09Z 2019-01-23 14:53:43 2018 book 31977 16648714 9782889455676 https://directory.doabooks.org/handle/20.500.12854/59061 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4275/the-search-for-biological-active-agents-from-actinobacteria Frontiers Media SA 10.3389/978-2-88945-567-6 10.3389/978-2-88945-567-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889455676 312 open access |
| spellingShingle | QR1-502 Q1-390 actinobacteria terrestrial drug discovery next generation Streptomyces marine bioactive thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) Learn-Han Lee Kok-Gan Chan Bey-Hing Goh Elizabeth M. H. Wellington Jem Stach The Search for Biological Active Agent(s) From Actinobacteria |
| title | The Search for Biological Active Agent(s) From Actinobacteria |
| title_full | The Search for Biological Active Agent(s) From Actinobacteria |
| title_fullStr | The Search for Biological Active Agent(s) From Actinobacteria |
| title_full_unstemmed | The Search for Biological Active Agent(s) From Actinobacteria |
| title_short | The Search for Biological Active Agent(s) From Actinobacteria |
| title_sort | search for biological active agent s from actinobacteria |
| topic | QR1-502 Q1-390 actinobacteria terrestrial drug discovery next generation Streptomyces marine bioactive thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| topic_facet | QR1-502 Q1-390 actinobacteria terrestrial drug discovery next generation Streptomyces marine bioactive thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) |
| url | 31977 |
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