Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy
Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of...
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| Định dạng: | Online |
| Ngôn ngữ: | Tiếng Anh |
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Frontiers Media SA
2021
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| Truy cập trực tuyến: | 29653 |
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| _version_ | 1869517831143424000 |
|---|---|
| author | Jon D. Lane Patrizia Agostinis |
| author_browse | Jon D. Lane Patrizia Agostinis |
| author_facet | Jon D. Lane Patrizia Agostinis |
| author_sort | Jon D. Lane |
| collection | Directory of Open Access Books |
| description | Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer. |
| format | Online |
| id | doab-20.500.12854ir-59184 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-591842024-03-30T23:22:11Z Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy Jon D. Lane Patrizia Agostinis R5-920 RC254-282 Pancreatic cancer Therapy miRNAs Cell death Tumor Microenvironment Anti-tumor immunity Hypoxia Autophagy Cell Division Cancer thema EDItEUR::M Medicine and Nursing Macroautophagy, the major lysosomal pathway for recycling intracellular components including whole organelles, has emerged as a key process modulating tumorigenesis, tumor–stroma interactions, and cancer therapy. An impressive number of studies over the past decade have unraveled the plastic role of autophagy during tumor development and dissemination. The discoveries that autophagy may either support or repress neoplastic growth and contextually favor or weaken resistance and impact antitumor immunity have spurred efforts from many laboratories trying to conceptualize the complex role of autophagy in cancer using cellular and preclinical models. This complexity is further accentuated by recent findings highlighting that various autophagy-related genes have roles beyond this catabolic mechanism and interface with oncogenic pathways, other trafficking and degradation mechanisms and the cell death machinery. From a therapeutic perspective, knowledge of how autophagy modulates the tumor microenvironment is crucial to devise autophagy-targeting strategies using smart combination of drugs or anticancer modalities. This eBook contains a collection of reviews by autophagy researchers and provides a background to the state-of-the-art in the field of autophagy in cancer, focusing on various aspects of autophagy regulation ranging from its molecular components to its cell autonomous role, e.g. in cell division and oncogenesis, miRNAs regulation, cross-talk with cell death pathways as well as cell non-autonomous role, e.g. in secretion, interface with tumor stroma and clinical prospects of autophagy-based biomarkers and autophagy modulators in anticancer therapy. This eBook is part of the TransAutophagy initiative to better understand the clinical implications of autophagy in cancer. 2021-02-12T03:19:04Z 2021-02-12T03:19:04Z 2018-11-16 17:17:57 2018 book 29653 16648714 9782889454228 https://directory.doabooks.org/handle/20.500.12854/59184 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/4833/self-eating-on-demand-autophagy-in-cancer-and-cancer-therapy Frontiers Media SA 10.3389/978-2-88945-422-8 10.3389/978-2-88945-422-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454228 111 open access |
| spellingShingle | R5-920 RC254-282 Pancreatic cancer Therapy miRNAs Cell death Tumor Microenvironment Anti-tumor immunity Hypoxia Autophagy Cell Division Cancer thema EDItEUR::M Medicine and Nursing Jon D. Lane Patrizia Agostinis Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy |
| title | Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy |
| title_full | Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy |
| title_fullStr | Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy |
| title_full_unstemmed | Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy |
| title_short | Self-Eating on Demand: Autophagy in Cancer and Cancer Therapy |
| title_sort | self eating on demand autophagy in cancer and cancer therapy |
| topic | R5-920 RC254-282 Pancreatic cancer Therapy miRNAs Cell death Tumor Microenvironment Anti-tumor immunity Hypoxia Autophagy Cell Division Cancer thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC254-282 Pancreatic cancer Therapy miRNAs Cell death Tumor Microenvironment Anti-tumor immunity Hypoxia Autophagy Cell Division Cancer thema EDItEUR::M Medicine and Nursing |
| url | 29653 |
| work_keys_str_mv | AT jondlane selfeatingondemandautophagyincancerandcancertherapy AT patriziaagostinis selfeatingondemandautophagyincancerandcancertherapy |