Sensory Hair Cell Death and Regeneration
Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acou...
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| Үндсэн зохиолчид: | , , |
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| Формат: | Online |
| Хэл сонгох: | англи |
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Frontiers Media SA
2021
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| Нөхцлүүд: | |
| Онлайн хандалт: | 22895 |
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Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!
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| _version_ | 1869515818675470336 |
|---|---|
| author | Michael E. Smith Allison B. Coffin Andrew K. Groves |
| author_browse | Allison B. Coffin Andrew K. Groves Michael E. Smith |
| author_facet | Michael E. Smith Allison B. Coffin Andrew K. Groves |
| author_sort | Michael E. Smith |
| collection | Directory of Open Access Books |
| description | Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future. |
| format | Online |
| id | doab-20.500.12854ir-59232 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-592322024-04-05T12:35:33Z Sensory Hair Cell Death and Regeneration Michael E. Smith Allison B. Coffin Andrew K. Groves RC321-571 Q1-390 Regeneration Neuromast ototoxicity Hair cells auditory Cell Death Cochlea Otoprotection Otic development Hearing Loss thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Sensory hair cells are the specialized mechanosensory receptors found in vertebrate auditory, vestibular, and lateral line organs that transduce vibratory and acoustic stimuli into the sensations of hearing and balance. Hair cells can be damaged due to such factors as aging, ototoxic chemicals, acoustic trauma, infection, or genetic factors. Loss of these hair cells lead to deficits in hearing and balance, and in mammals, such deficits are permanent. In contrast, non-mammalian vertebrates exhibit the capability to regenerate missing hair cells. Researchers have been examining the process of hair cell death and regeneration in animal models in an attempt to find ways of either preventing hair cell loss or stimulating the production of new hair cells in mammals, with the ultimate goal of finding new therapeutics for human sensorineural hearing and balance deficits. This has led to a wide array of research on sensory hair cells- such as understanding the factors that cause hair cell loss and finding agents that protect them from damage, elucidating the cell signaling pathways activated during hair cell death, examining the genes and cellular pathways that are regulated during the process of hair cell death and regeneration, and characterizing the functional sensory loss and recovery following acoustic or ototoxic insults to the inner ear. This research has involved cell and developmental biologists, physiologists, geneticists, bioinformaticians, and otolaryngologists. In this Research Topic, we have collated reviews of the past progress of hair cell death and regeneration studies and original research articles advancing sensory hair cell death and regeneration research into the future. 2021-02-12T03:22:40Z 2021-02-12T03:22:40Z 2017-07-06 13:27:36 2016 book 22895 16648714 9782889450008 https://directory.doabooks.org/handle/20.500.12854/59232 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Sensory_Hair_Cell_Death_and_Regeneration/1079#nogo http://journal.frontiersin.org/researchtopic/2730/sensory-hair-cell-death-and-regeneration Frontiers Media SA 10.3389/978-2-88945-000-8 10.3389/978-2-88945-000-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889450008 266 open access |
| spellingShingle | RC321-571 Q1-390 Regeneration Neuromast ototoxicity Hair cells auditory Cell Death Cochlea Otoprotection Otic development Hearing Loss thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Michael E. Smith Allison B. Coffin Andrew K. Groves Sensory Hair Cell Death and Regeneration |
| title | Sensory Hair Cell Death and Regeneration |
| title_full | Sensory Hair Cell Death and Regeneration |
| title_fullStr | Sensory Hair Cell Death and Regeneration |
| title_full_unstemmed | Sensory Hair Cell Death and Regeneration |
| title_short | Sensory Hair Cell Death and Regeneration |
| title_sort | sensory hair cell death and regeneration |
| topic | RC321-571 Q1-390 Regeneration Neuromast ototoxicity Hair cells auditory Cell Death Cochlea Otoprotection Otic development Hearing Loss thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Regeneration Neuromast ototoxicity Hair cells auditory Cell Death Cochlea Otoprotection Otic development Hearing Loss thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 22895 |
| work_keys_str_mv | AT michaelesmith sensoryhaircelldeathandregeneration AT allisonbcoffin sensoryhaircelldeathandregeneration AT andrewkgroves sensoryhaircelldeathandregeneration |