Significance of antigen and epitope specificity in tuberculosis
Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the T...
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| Formatua: | Online |
| Hizkuntza: | ingelesa |
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Frontiers Media SA
2021
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| Sarrera elektronikoa: | 18597 |
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| _version_ | 1869516805417992192 |
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| author | Tom H.M. Ottenhoff Juraj Ivanyi |
| author_browse | Juraj Ivanyi Tom H.M. Ottenhoff |
| author_facet | Tom H.M. Ottenhoff Juraj Ivanyi |
| author_sort | Tom H.M. Ottenhoff |
| collection | Directory of Open Access Books |
| description | Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis. |
| format | Online |
| id | doab-20.500.12854ir-59367 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-593672024-03-30T23:21:57Z Significance of antigen and epitope specificity in tuberculosis Tom H.M. Ottenhoff Juraj Ivanyi R5-920 RC581-607 Antigens Tuberculosis bacterial MHC restriction TB diagnosis T-lymphocyte vaccine adjuvant Epitopes thema EDItEUR::M Medicine and Nursing Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis. 2021-02-12T03:35:21Z 2021-02-12T03:35:21Z 2016-02-05 17:24:33 2014 book 18597 16648714 9782889194513 https://directory.doabooks.org/handle/20.500.12854/59367 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Significance_of_antigen_and_epitope_specificity_in_tuberculosis/391#nogo http://journal.frontiersin.org/researchtopic/1771/significance-of-antigen-and-epitope-specificity-in-tuberculosis Frontiers Media SA 10.3389/978-2-88919-451-3 10.3389/978-2-88919-451-3 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889194513 119 open access |
| spellingShingle | R5-920 RC581-607 Antigens Tuberculosis bacterial MHC restriction TB diagnosis T-lymphocyte vaccine adjuvant Epitopes thema EDItEUR::M Medicine and Nursing Tom H.M. Ottenhoff Juraj Ivanyi Significance of antigen and epitope specificity in tuberculosis |
| title | Significance of antigen and epitope specificity in tuberculosis |
| title_full | Significance of antigen and epitope specificity in tuberculosis |
| title_fullStr | Significance of antigen and epitope specificity in tuberculosis |
| title_full_unstemmed | Significance of antigen and epitope specificity in tuberculosis |
| title_short | Significance of antigen and epitope specificity in tuberculosis |
| title_sort | significance of antigen and epitope specificity in tuberculosis |
| topic | R5-920 RC581-607 Antigens Tuberculosis bacterial MHC restriction TB diagnosis T-lymphocyte vaccine adjuvant Epitopes thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 Antigens Tuberculosis bacterial MHC restriction TB diagnosis T-lymphocyte vaccine adjuvant Epitopes thema EDItEUR::M Medicine and Nursing |
| url | 18597 |
| work_keys_str_mv | AT tomhmottenhoff significanceofantigenandepitopespecificityintuberculosis AT jurajivanyi significanceofantigenandepitopespecificityintuberculosis |