Single-Domain Antibodies: Biology, Engineering and Emerging Applications
Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but c...
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| প্রধান লেখক: | , |
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
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Frontiers Media SA
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 29661 |
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| _version_ | 1869526512196124672 |
|---|---|
| author | Kevin A. Henry C. Roger MacKenzie |
| author_browse | C. Roger MacKenzie Kevin A. Henry |
| author_facet | Kevin A. Henry C. Roger MacKenzie |
| author_sort | Kevin A. Henry |
| collection | Directory of Open Access Books |
| description | Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics. |
| format | Online |
| id | doab-20.500.12854ir-59417 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-594172024-03-31T13:09:47Z Single-Domain Antibodies: Biology, Engineering and Emerging Applications Kevin A. Henry C. Roger MacKenzie R5-920 RC581-607 antibody engineering antibody discovery therapeutic antibody diagnostic antibody single-domain antibody thema EDItEUR::M Medicine and Nursing Single-domain antibodies (sdAbs) represent the minimal antigen binding-competent form of the immunoglobulin domain and have unique properties and applications. SdAbs are naturally produced as the variable domains of the heavy chain-only antibodies of camelid ruminants and cartilaginous fishes, but can also be engineered synthetically from autonomous human or mouse VH or VL domains. The scope of this research topic and associated e-book covers current understanding and new developments in (i) the biology, immunology and immunogenetics of sdAbs in camelids and cartilaginous fishes, (ii) strategies for sdAb discovery, (iii) protein engineering approaches to increase the solubility, stability and antigen-binding affinity of sdAbs and (iv) specialized applications of sdAbs in areas such diagnostics, imaging and therapeutics. 2021-02-12T03:38:38Z 2021-02-12T03:38:38Z 2018-11-16 17:17:57 2018 book 29661 16648714 9782889454327 https://directory.doabooks.org/handle/20.500.12854/59417 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5098/single-domain-antibodies-biology-engineering-and-emerging-applications Frontiers Media SA 10.3389/978-2-88945-432-7 10.3389/978-2-88945-432-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889454327 338 open access |
| spellingShingle | R5-920 RC581-607 antibody engineering antibody discovery therapeutic antibody diagnostic antibody single-domain antibody thema EDItEUR::M Medicine and Nursing Kevin A. Henry C. Roger MacKenzie Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title | Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_full | Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_fullStr | Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_full_unstemmed | Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_short | Single-Domain Antibodies: Biology, Engineering and Emerging Applications |
| title_sort | single domain antibodies biology engineering and emerging applications |
| topic | R5-920 RC581-607 antibody engineering antibody discovery therapeutic antibody diagnostic antibody single-domain antibody thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 antibody engineering antibody discovery therapeutic antibody diagnostic antibody single-domain antibody thema EDItEUR::M Medicine and Nursing |
| url | 29661 |
| work_keys_str_mv | AT kevinahenry singledomainantibodiesbiologyengineeringandemergingapplications AT crogermackenzie singledomainantibodiesbiologyengineeringandemergingapplications |