Stem Cell and Biologic Scaffold Engineering
Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering...
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| Format: | Online |
| Jezik: | angleščina |
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MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Online dostop: | 42566 |
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| _version_ | 1869521568007192576 |
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| author | Mallis, Panagiotis |
| author_browse | Mallis, Panagiotis |
| author_facet | Mallis, Panagiotis |
| author_sort | Mallis, Panagiotis |
| collection | Directory of Open Access Books |
| description | Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches. |
| format | Online |
| id | doab-20.500.12854ir-60016 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-600162024-04-05T12:32:41Z Stem Cell and Biologic Scaffold Engineering Mallis, Panagiotis QH301-705.5 Q1-390 nerve conduit tissue engineering regenerative medicine mixed lymphocyte reaction histological images future scaffold engineering multiparameter 3DPVS MSCs Wnt signaling Mesenchymal Stromal Cells factorial design novel scaffold Wharton’s Jelly tissue stem cells umbilical arteries SDS platelet rich plasma TGF? signaling traditional scaffold pluripotency and commitment tissue engineered construct HLA-G CHAPS platelets proteomic analysis vibrating nature of universe. VS55 cell culture FGF signaling evolution of scaffold dynamicity and dimensionality fibrin gel scaffold classification decellularization vitrification seven-folder logics IIEF-5 questionnaire TGF-?1 erectile dysfunction human induced pluripotent stem cells iPSCs scaffolds Barret’s esophagus nerve regeneration long term storage laws of system evolution scaffold categorization platelet lysate 3D scaffold esophagus language of relativity cord blood units thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Tissue engineering and regenerative medicine is a rapidly evolving research field which effectively combines stem cells and biologic scaffolds in order to replace damaged tissues. Biologic scaffolds can be produced through the removal of resident cellular populations using several tissue engineering approaches, such as the decellularization method. Indeed, the decellularization method aims to develop a cell-free biologic scaffold while keeping the extracellular matrix (ECM) intact. Furthermore, biologic scaffolds have been investigated for their in vitro potential for whole organ development. Currently, clinical products composed of decellularized matrices, such as pericardium, urinary bladder, small intestine, heart valves, nerve conduits, trachea, and vessels, are being evaluated for use in human clinical trials. Tissue engineering strategies require the interaction of biologic scaffolds with cellular populations. Among them, stem cells are characterized by unlimited cell division, self-renewal, and differentiation potential, distinguishing themselves as a frontline source for the repopulation of decellularized matrices and scaffolds. Under this scheme, stem cells can be isolated from patients, expanded under good manufacturing practices (GMPs), used for the repopulation of biologic scaffolds and, finally, returned to the patient. The interaction between scaffolds and stem cells is thought to be crucial for their infiltration, adhesion, and differentiation into specific cell types. In addition, biomedical devices such as bioreactors contribute to the uniform repopulation of scaffolds. Until now, remarkable efforts have been made by the scientific society in order to establish the proper repopulation conditions of decellularized matrices and scaffolds. However, parameters such as stem cell number, in vitro cultivation conditions, and specific growth media composition need further evaluation. The ultimate goal is the development of “artificial” tissues similar to native ones, which is achieved by properly combining stem cells and biologic scaffolds and thus bringing them one step closer to personalized medicine. The original research articles and comprehensive reviews in this Special Issue deal with the use of stem cells and biologic scaffolds that utilize state-of-the-art tissue engineering and regenerative medicine approaches. 2021-02-12T04:32:17Z 2021-02-12T04:32:17Z 2019-12-09 11:49:15 2019 book 42566 9783039214976 9783039214983 https://directory.doabooks.org/handle/20.500.12854/60016 eng application/octet-stream Attribution-NonCommercial-NoDerivatives 4.0 International https://mdpi.com/books/pdfview/book/1650 MDPI - Multidisciplinary Digital Publishing Institute 10.3390/books978-3-03921-498-3 10.3390/books978-3-03921-498-3 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783039214976 9783039214983 110 open access |
| spellingShingle | QH301-705.5 Q1-390 nerve conduit tissue engineering regenerative medicine mixed lymphocyte reaction histological images future scaffold engineering multiparameter 3DPVS MSCs Wnt signaling Mesenchymal Stromal Cells factorial design novel scaffold Wharton’s Jelly tissue stem cells umbilical arteries SDS platelet rich plasma TGF? signaling traditional scaffold pluripotency and commitment tissue engineered construct HLA-G CHAPS platelets proteomic analysis vibrating nature of universe. VS55 cell culture FGF signaling evolution of scaffold dynamicity and dimensionality fibrin gel scaffold classification decellularization vitrification seven-folder logics IIEF-5 questionnaire TGF-?1 erectile dysfunction human induced pluripotent stem cells iPSCs scaffolds Barret’s esophagus nerve regeneration long term storage laws of system evolution scaffold categorization platelet lysate 3D scaffold esophagus language of relativity cord blood units thema EDItEUR::P Mathematics and Science::PS Biology, life sciences Mallis, Panagiotis Stem Cell and Biologic Scaffold Engineering |
| title | Stem Cell and Biologic Scaffold Engineering |
| title_full | Stem Cell and Biologic Scaffold Engineering |
| title_fullStr | Stem Cell and Biologic Scaffold Engineering |
| title_full_unstemmed | Stem Cell and Biologic Scaffold Engineering |
| title_short | Stem Cell and Biologic Scaffold Engineering |
| title_sort | stem cell and biologic scaffold engineering |
| topic | QH301-705.5 Q1-390 nerve conduit tissue engineering regenerative medicine mixed lymphocyte reaction histological images future scaffold engineering multiparameter 3DPVS MSCs Wnt signaling Mesenchymal Stromal Cells factorial design novel scaffold Wharton’s Jelly tissue stem cells umbilical arteries SDS platelet rich plasma TGF? signaling traditional scaffold pluripotency and commitment tissue engineered construct HLA-G CHAPS platelets proteomic analysis vibrating nature of universe. VS55 cell culture FGF signaling evolution of scaffold dynamicity and dimensionality fibrin gel scaffold classification decellularization vitrification seven-folder logics IIEF-5 questionnaire TGF-?1 erectile dysfunction human induced pluripotent stem cells iPSCs scaffolds Barret’s esophagus nerve regeneration long term storage laws of system evolution scaffold categorization platelet lysate 3D scaffold esophagus language of relativity cord blood units thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| topic_facet | QH301-705.5 Q1-390 nerve conduit tissue engineering regenerative medicine mixed lymphocyte reaction histological images future scaffold engineering multiparameter 3DPVS MSCs Wnt signaling Mesenchymal Stromal Cells factorial design novel scaffold Wharton’s Jelly tissue stem cells umbilical arteries SDS platelet rich plasma TGF? signaling traditional scaffold pluripotency and commitment tissue engineered construct HLA-G CHAPS platelets proteomic analysis vibrating nature of universe. VS55 cell culture FGF signaling evolution of scaffold dynamicity and dimensionality fibrin gel scaffold classification decellularization vitrification seven-folder logics IIEF-5 questionnaire TGF-?1 erectile dysfunction human induced pluripotent stem cells iPSCs scaffolds Barret’s esophagus nerve regeneration long term storage laws of system evolution scaffold categorization platelet lysate 3D scaffold esophagus language of relativity cord blood units thema EDItEUR::P Mathematics and Science::PS Biology, life sciences |
| url | 42566 |
| work_keys_str_mv | AT mallispanagiotis stemcellandbiologicscaffoldengineering |