Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites
Activity of the multi-functional networked neurons depends on their intrinsic states and bears both cell- and network-defined features. Firing patterns of a neuron are conventionally attributed to spatial-temporal organization of inputs received from the network-mates via synapses, in vast majority...
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| Materyal Türü: | Online |
| Dil: | İngilizce |
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Frontiers Media SA
2021
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| Online Erişim: | 32006 |
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| _version_ | 1869529860306632704 |
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| author | Sergey M. Korogod |
| author_browse | Sergey M. Korogod |
| author_facet | Sergey M. Korogod |
| author_sort | Sergey M. Korogod |
| collection | Directory of Open Access Books |
| description | Activity of the multi-functional networked neurons depends on their intrinsic states and bears both cell- and network-defined features. Firing patterns of a neuron are conventionally attributed to spatial-temporal organization of inputs received from the network-mates via synapses, in vast majority dendritic. This attribution reflects widespread views of the within-cell job sharing, such that the main function of the dendrites is to receive signals and deliver them to the axo-somatic trigger zone, which actually generates the output pattern. However, these views are now revisited due to finding of active, non-linear properties of the dendritic membrane practically in neurons of practically all explored types. Like soma and axon, the dendrites with active membrane are able to generate self-maintained, propagating depolarizations and thus share intrinsic pattern-forming role with the trigger zone. Unlike the trigger zone, the dendrites have complex geometry, which is subject to developmental, activity-dependent, or neurodegenerative changes. Structural features of the arborization inevitably impact on electrical states and cooperative behavior of its constituting parts at different levels of organization, from sub-trees and branches to voltage- and ligand-gated ion channels populating the dendritic membrane. More than two decades of experimental and computer simulation studies have brought numerous phenomenological demonstrations of influence of the dendritic structure on neuronal firing patterns. A necessary step forward is to comprehend these findings and build a firm theoretical basis, including quantitative relationships between geometrical and electrical characteristics determining intrinsic activity of neurons. The articles in this eBook represent progress achieved in a broad circle of laboratories studied various aspects of structure and function of the neuronal dendrites. The authors elucidate new details of dendritic mechanisms underlying intrinsic activity patterns in neurons and highlight important questions that remain open in this important domain of cellular and computational neuroscience. |
| format | Online |
| id | doab-20.500.12854ir-60158 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-601582024-04-05T17:30:15Z Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites Sergey M. Korogod RC321-571 Q1-390 activity patterns functional compartmentalization Neurons synaptic action voltage-gated channels electrical states dendritic arborization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Activity of the multi-functional networked neurons depends on their intrinsic states and bears both cell- and network-defined features. Firing patterns of a neuron are conventionally attributed to spatial-temporal organization of inputs received from the network-mates via synapses, in vast majority dendritic. This attribution reflects widespread views of the within-cell job sharing, such that the main function of the dendrites is to receive signals and deliver them to the axo-somatic trigger zone, which actually generates the output pattern. However, these views are now revisited due to finding of active, non-linear properties of the dendritic membrane practically in neurons of practically all explored types. Like soma and axon, the dendrites with active membrane are able to generate self-maintained, propagating depolarizations and thus share intrinsic pattern-forming role with the trigger zone. Unlike the trigger zone, the dendrites have complex geometry, which is subject to developmental, activity-dependent, or neurodegenerative changes. Structural features of the arborization inevitably impact on electrical states and cooperative behavior of its constituting parts at different levels of organization, from sub-trees and branches to voltage- and ligand-gated ion channels populating the dendritic membrane. More than two decades of experimental and computer simulation studies have brought numerous phenomenological demonstrations of influence of the dendritic structure on neuronal firing patterns. A necessary step forward is to comprehend these findings and build a firm theoretical basis, including quantitative relationships between geometrical and electrical characteristics determining intrinsic activity of neurons. The articles in this eBook represent progress achieved in a broad circle of laboratories studied various aspects of structure and function of the neuronal dendrites. The authors elucidate new details of dendritic mechanisms underlying intrinsic activity patterns in neurons and highlight important questions that remain open in this important domain of cellular and computational neuroscience. 2021-02-12T04:45:06Z 2021-02-12T04:45:06Z 2019-01-23 14:53:43 2018 book 32006 16648714 9782889456086 https://directory.doabooks.org/handle/20.500.12854/60158 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/1933/structure-related-intrinsic-electrical-states-and-firing-patterns-of-neurons-with-active-dendrites Frontiers Media SA 10.3389/978-2-88945-608-6 10.3389/978-2-88945-608-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456086 296 open access |
| spellingShingle | RC321-571 Q1-390 activity patterns functional compartmentalization Neurons synaptic action voltage-gated channels electrical states dendritic arborization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Sergey M. Korogod Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites |
| title | Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites |
| title_full | Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites |
| title_fullStr | Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites |
| title_full_unstemmed | Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites |
| title_short | Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites |
| title_sort | structure related intrinsic electrical states and firing patterns of neurons with active dendrites |
| topic | RC321-571 Q1-390 activity patterns functional compartmentalization Neurons synaptic action voltage-gated channels electrical states dendritic arborization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 activity patterns functional compartmentalization Neurons synaptic action voltage-gated channels electrical states dendritic arborization thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 32006 |
| work_keys_str_mv | AT sergeymkorogod structurerelatedintrinsicelectricalstatesandfiringpatternsofneuronswithactivedendrites |