Sudden arrhythmic death: From basic science to clinical practice
With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a m...
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| Formato: | Online |
| Idioma: | inglês |
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Frontiers Media SA
2021
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| Acesso em linha: | 17777 |
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| _version_ | 1869526892297584640 |
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| author | Ian N. Sabir Gareth D. Matthews Christopher LH Huang |
| author_browse | Christopher LH Huang Gareth D. Matthews Ian N. Sabir |
| author_facet | Ian N. Sabir Gareth D. Matthews Christopher LH Huang |
| author_sort | Ian N. Sabir |
| collection | Directory of Open Access Books |
| description | With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future. |
| format | Online |
| id | doab-20.500.12854ir-60236 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-602362024-03-31T22:45:13Z Sudden arrhythmic death: From basic science to clinical practice Ian N. Sabir Gareth D. Matthews Christopher LH Huang QP1-981 Q1-390 ventricular arrhythmia Inherited arrhythmia syndromes sudden death arrhythmia mechanisms Channelopathies ventricular tachycardia cardiac modelling Ventricular Fibrillation Atrial Fibrillation Brugada Syndrome thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology With upwards of 4.5 million deaths worldwide each year, and more than one tenth of these occurring in those with no previously documented heart disease, sudden arrhythmic death (SAD) is both a major public health burden and a highly emotive issue for society at large. Recent years have witnessed a marked expansion in our knowledge of the physiology underlying SAD, both in the context of hereditary and acquired cardiac disorders. Thanks largely to work in genetically modified animals, the growth in our understanding of mechanisms underlying arrhythmia in the hereditary channelopathies has been particularly marked. Our growing knowledge of the fundamental mechanisms underlying SAD has so far failed to spur substantial developments in clinical practice. Despite a large body of work in both humans and animals, it remains impossible to confidently identify those at high risk of SAD, making pre-emptive therapy a challenge. What is more, with the thankful exception of the implantable cardioverter-defibrillators and pharmacological agents in very specific situations, there has been depressingly little progress in finding new and effective therapies. This Research Topic aims to go some way towards bridging the gap between advances in basic science and the development and delivery of new therapies. It brings together original research contributions and review articles from key opinion leaders in the field, focusing on the direct clinical implications of the basic science research now and in the future. 2021-02-12T04:50:03Z 2021-02-12T04:50:03Z 2015-12-03 13:02:24 2014 book 17777 16648714 9782889192694 https://directory.doabooks.org/handle/20.500.12854/60236 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Sudden_arrhythmic_death_from_basic_science_to_clinical_practice/322#nogo http://journal.frontiersin.org/researchtopic/1015/sudden-arrhythmic-death-from-basic-science-to-clinical-practice Frontiers Media SA 10.3389/978-2-88919-269-4 10.3389/978-2-88919-269-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192694 136 open access |
| spellingShingle | QP1-981 Q1-390 ventricular arrhythmia Inherited arrhythmia syndromes sudden death arrhythmia mechanisms Channelopathies ventricular tachycardia cardiac modelling Ventricular Fibrillation Atrial Fibrillation Brugada Syndrome thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Ian N. Sabir Gareth D. Matthews Christopher LH Huang Sudden arrhythmic death: From basic science to clinical practice |
| title | Sudden arrhythmic death: From basic science to clinical practice |
| title_full | Sudden arrhythmic death: From basic science to clinical practice |
| title_fullStr | Sudden arrhythmic death: From basic science to clinical practice |
| title_full_unstemmed | Sudden arrhythmic death: From basic science to clinical practice |
| title_short | Sudden arrhythmic death: From basic science to clinical practice |
| title_sort | sudden arrhythmic death from basic science to clinical practice |
| topic | QP1-981 Q1-390 ventricular arrhythmia Inherited arrhythmia syndromes sudden death arrhythmia mechanisms Channelopathies ventricular tachycardia cardiac modelling Ventricular Fibrillation Atrial Fibrillation Brugada Syndrome thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 Q1-390 ventricular arrhythmia Inherited arrhythmia syndromes sudden death arrhythmia mechanisms Channelopathies ventricular tachycardia cardiac modelling Ventricular Fibrillation Atrial Fibrillation Brugada Syndrome thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 17777 |
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