Synaptic Assembly and Neural Circuit Development
Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the centra...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Online |
| Sprache: | Englisch |
| Veröffentlicht: |
Frontiers Media SA
2021
|
| Schlagworte: | |
| Online-Zugang: | 32028 |
| Tags: |
Keine Tags, Fügen Sie das erste Tag hinzu!
|
| _version_ | 1869524775326449664 |
|---|---|
| author | Jaewon Ko Chen Zhang |
| author_browse | Chen Zhang Jaewon Ko |
| author_facet | Jaewon Ko Chen Zhang |
| author_sort | Jaewon Ko |
| collection | Directory of Open Access Books |
| description | Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the central nervous system critically depends on the establishment of ‘precise’ synaptic connections between neurons and specific target cells. During synaptogenesis, synapses form, mature, stabilize, and are eliminated through processes that require intimate communication between pre- and postsynaptic partners. The sequential and/or parallel processes dictate the wiring of neural circuits in a rapid and dynamic fashion. Accumulating evidence suggests that activity-dependent synaptic and circuit plasticity reflects the assembly and disassembly of diverse synapses that occur in a distinctive manner in specific neuron types. In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations. |
| format | Online |
| id | doab-20.500.12854ir-60393 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-603932024-04-05T17:30:53Z Synaptic Assembly and Neural Circuit Development Jaewon Ko Chen Zhang RC321-571 Q1-390 Synaptic adhesion molecule Neuron neural circuit assembly recognition synapse thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Synapses are fundamental signaling units of the central nervous system that mediate communication between individual neurons, participate in the computation of neuronal networks, and process information through long-term modification of their strength and structure. The normal function of the central nervous system critically depends on the establishment of ‘precise’ synaptic connections between neurons and specific target cells. During synaptogenesis, synapses form, mature, stabilize, and are eliminated through processes that require intimate communication between pre- and postsynaptic partners. The sequential and/or parallel processes dictate the wiring of neural circuits in a rapid and dynamic fashion. Accumulating evidence suggests that activity-dependent synaptic and circuit plasticity reflects the assembly and disassembly of diverse synapses that occur in a distinctive manner in specific neuron types. In this Research Topic, our purpose is to compile the latest developments in our understanding of molecular and cellular mechanisms underlying pre- and postsynaptic assembly, specification of synaptic adhesion pathways, presynaptic neurotransmitter release and postsynaptic receptor trafficking. In addition, non-neuronal cell processes involved in dismantling and eliminating synapses and relevant neural circuits will be covered. Clinical implications of this research topic will be considered, emphasizing the importance of these basic neuroscience research activities for translational and therapeutic applications. This includes literature describing recent methodologies for probing key issues regarding assembly/disassembly of synapses and circuits as well as primary research articles that provide critical insights into these fundamental questions in various model systems and experimental preparations. 2021-02-12T05:05:16Z 2021-02-12T05:05:16Z 2019-01-23 14:53:43 2018 book 32028 16648714 9782889456307 https://directory.doabooks.org/handle/20.500.12854/60393 eng Frontiers Research Topics image/jpeg Attribution 4.0 International https://www.frontiersin.org/research-topics/5517/synaptic-assembly-and-neural-circuit-development Frontiers Media SA 10.3389/978-2-88945-630-7 10.3389/978-2-88945-630-7 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889456307 191 open access |
| spellingShingle | RC321-571 Q1-390 Synaptic adhesion molecule Neuron neural circuit assembly recognition synapse thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences Jaewon Ko Chen Zhang Synaptic Assembly and Neural Circuit Development |
| title | Synaptic Assembly and Neural Circuit Development |
| title_full | Synaptic Assembly and Neural Circuit Development |
| title_fullStr | Synaptic Assembly and Neural Circuit Development |
| title_full_unstemmed | Synaptic Assembly and Neural Circuit Development |
| title_short | Synaptic Assembly and Neural Circuit Development |
| title_sort | synaptic assembly and neural circuit development |
| topic | RC321-571 Q1-390 Synaptic adhesion molecule Neuron neural circuit assembly recognition synapse thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| topic_facet | RC321-571 Q1-390 Synaptic adhesion molecule Neuron neural circuit assembly recognition synapse thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences |
| url | 32028 |
| work_keys_str_mv | AT jaewonko synapticassemblyandneuralcircuitdevelopment AT chenzhang synapticassemblyandneuralcircuitdevelopment |