Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders
Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both...
Saved in:
| Main Authors: | , , |
|---|---|
| 格式: | Online |
| 語言: | 英语 |
| 出版: |
Frontiers Media SA
2021
|
| 主題: | |
| 在線閱讀: | 17660 |
| 標簽: |
沒有標簽, 成為第一個標記此記錄!
|
| _version_ | 1869528079153496064 |
|---|---|
| author | Pankaj Qasba Raimond L Winslow Jennie Larkin |
| author_browse | Jennie Larkin Pankaj Qasba Raimond L Winslow |
| author_facet | Pankaj Qasba Raimond L Winslow Jennie Larkin |
| author_sort | Pankaj Qasba |
| collection | Directory of Open Access Books |
| description | Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding. This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations. The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders. This Research Topic will be of great interest to the cardiovascular research community as well as to the general community of systems biologists. |
| format | Online |
| id | doab-20.500.12854ir-60440 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-604402024-03-31T22:45:15Z Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders Pankaj Qasba Raimond L Winslow Jennie Larkin QP1-981 TP248.13-248.65 TA1-2040 Q1-390 sepsis models immune system models micro-RNA networks pulmonary models Computational Medicine cardiac models thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Development of powerful new high- throughput technologies for probing the transcriptome, proteome and metabolome is driving the rapid acquisition of information on the function of molecular systems. The importance of these achievements cannot be understated - they have transformed the nature of both biology and medicine. Despite this dramatic progress, one of the greatest challenges that continues to confront modern biology is to understand how behavior at the level of genome, proteome and metabolome determines physiological function at the level of cell, tissue and organ in both health and disease. Because of the inherent complexity of biological systems, the development, analysis, and validation of integrative computational models based directly on experimental data is necessary to achieve this understanding. This approach, known as systems biology, integrates computational and experimental approaches through iterative development of mathematical models and experimental validation and testing. The combination of these approaches allows for a mechanistic understanding of the function of complex biological systems in health and their dysfunction in disease. The National Heart, Lung, and Blood Institute (NHLBI) has recognized the importance of the systems biology approach for understanding normal physiology and perturbations associated with heart, lung, blood, and sleep diseases and disorders. In 2006, NHLBI announced the Exploratory Program in Systems Biology, followed in 2010 by the NHLBI Systems Biology Collaborations. The goal of these programs is to support collaborative teams of investigators in using experimental and computational strategies to integrate the component parts of biological networks and pathways into computational models that are based firmly on and validated using experimental data. These validated models are then applied to gain insights into the mechanisms of altered system function in disease, to generate novel hypotheses regarding these mechanisms that can be tested experimentally, and to then use the results of experiments to refine the models. The purpose of this Research Topic is to present the range of innovative, new approaches being developed by investigators working in areas of systems biology that couple experimental and modeling studies to understand the cause and possible treatment of heart, lung, blood and sleep diseases and disorders. This Research Topic will be of great interest to the cardiovascular research community as well as to the general community of systems biologists. 2021-02-12T05:09:52Z 2021-02-12T05:09:52Z 2015-11-16 15:44:59 2014 book 17660 16648714 9782889192496 https://directory.doabooks.org/handle/20.500.12854/60440 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Systems_Biology_Approaches_to_Understanding_the_Cause_and_Treatment_of_Heart_Lung_Blood_and_Sleep_D/365#nogo http://journal.frontiersin.org/researchtopic/613/systems-biology-approaches-to-understanding-the-cause-and-treatment-of-heart-lung-blood-and-sleep-di Frontiers Media SA 10.3389/978-2-88919-249-6 10.3389/978-2-88919-249-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192496 180 open access |
| spellingShingle | QP1-981 TP248.13-248.65 TA1-2040 Q1-390 sepsis models immune system models micro-RNA networks pulmonary models Computational Medicine cardiac models thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology Pankaj Qasba Raimond L Winslow Jennie Larkin Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders |
| title | Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders |
| title_full | Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders |
| title_fullStr | Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders |
| title_full_unstemmed | Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders |
| title_short | Systems Biology Approaches to Understanding the Cause and Treatment of Heart, Lung, Blood, and Sleep Disorders |
| title_sort | systems biology approaches to understanding the cause and treatment of heart lung blood and sleep disorders |
| topic | QP1-981 TP248.13-248.65 TA1-2040 Q1-390 sepsis models immune system models micro-RNA networks pulmonary models Computational Medicine cardiac models thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| topic_facet | QP1-981 TP248.13-248.65 TA1-2040 Q1-390 sepsis models immune system models micro-RNA networks pulmonary models Computational Medicine cardiac models thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology |
| url | 17660 |
| work_keys_str_mv | AT pankajqasba systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders AT raimondlwinslow systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders AT jennielarkin systemsbiologyapproachestounderstandingthecauseandtreatmentofheartlungbloodandsleepdisorders |