T Cell Regulation by the Environment
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset de...
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| Váldodahkkit: | , |
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| Materiálatiipa: | Online |
| Giella: | eaŋgalasgiella |
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Frontiers Media SA
2021
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| Fáttát: | |
| Liŋkkat: | 18854 |
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| _version_ | 1869523748293443584 |
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| author | Anne L. Astier David A. Hafler |
| author_browse | Anne L. Astier David A. Hafler |
| author_facet | Anne L. Astier David A. Hafler |
| author_sort | Anne L. Astier |
| collection | Directory of Open Access Books |
| description | Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses. |
| format | Online |
| id | doab-20.500.12854ir-60449 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-604492024-03-31T13:09:58Z T Cell Regulation by the Environment Anne L. Astier David A. Hafler R5-920 RC581-607 regulatory T cells Vitamin D helminth T cells Metabolism microbiome thema EDItEUR::M Medicine and Nursing Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses. 2021-02-12T05:10:45Z 2021-02-12T05:10:45Z 2016-04-07 11:22:02 2015 book 18854 16648714 9782889197330 https://directory.doabooks.org/handle/20.500.12854/60449 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/T_Cell_Regulation_by_the_Environment/741 http://journal.frontiersin.org/researchtopic/2582/t-cell-regulation-by-the-environment Frontiers Media SA 10.3389/978-2-88919-733-0 10.3389/978-2-88919-733-0 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197330 115 open access |
| spellingShingle | R5-920 RC581-607 regulatory T cells Vitamin D helminth T cells Metabolism microbiome thema EDItEUR::M Medicine and Nursing Anne L. Astier David A. Hafler T Cell Regulation by the Environment |
| title | T Cell Regulation by the Environment |
| title_full | T Cell Regulation by the Environment |
| title_fullStr | T Cell Regulation by the Environment |
| title_full_unstemmed | T Cell Regulation by the Environment |
| title_short | T Cell Regulation by the Environment |
| title_sort | t cell regulation by the environment |
| topic | R5-920 RC581-607 regulatory T cells Vitamin D helminth T cells Metabolism microbiome thema EDItEUR::M Medicine and Nursing |
| topic_facet | R5-920 RC581-607 regulatory T cells Vitamin D helminth T cells Metabolism microbiome thema EDItEUR::M Medicine and Nursing |
| url | 18854 |
| work_keys_str_mv | AT annelastier tcellregulationbytheenvironment AT davidahafler tcellregulationbytheenvironment |