Tau oligomers

Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer's Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity...

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Glavni autori: Jesus Avila, Naruhiko Sahara
Format: Online
Jezik:engleski
Izdano: Frontiers Media SA 2021
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author Jesus Avila
Naruhiko Sahara
author_browse Jesus Avila
Naruhiko Sahara
author_facet Jesus Avila
Naruhiko Sahara
author_sort Jesus Avila
collection Directory of Open Access Books
description Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer's Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a "toxic" form of tau protein. Moreover, it was suggested that a "toxic" tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, "tau oligomers" as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of "tau oligomers".
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spelling doab-20.500.12854ir-604942024-04-01T14:15:12Z Tau oligomers Jesus Avila Naruhiko Sahara RC346-429 R5-920 RC321-571 RC435-571 Q1-390 Tau phosphorylation neurodegenerative disease propagation Tauopathy tau protein thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer's Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a "toxic" form of tau protein. Moreover, it was suggested that a "toxic" tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, "tau oligomers" as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of "tau oligomers". 2021-02-12T05:15:24Z 2021-02-12T05:15:24Z 2015-12-03 13:02:24 2014 book 17770 16648714 9782889192618 https://directory.doabooks.org/handle/20.500.12854/60494 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Tau_oligomers/299 http://journal.frontiersin.org/researchtopic/1231/tau-oligomers Frontiers Media SA 10.3389/978-2-88919-261-8 10.3389/978-2-88919-261-8 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889192618 113 open access
spellingShingle RC346-429
R5-920
RC321-571
RC435-571
Q1-390
Tau phosphorylation
neurodegenerative disease
propagation
Tauopathy
tau protein
thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
Jesus Avila
Naruhiko Sahara
Tau oligomers
title Tau oligomers
title_full Tau oligomers
title_fullStr Tau oligomers
title_full_unstemmed Tau oligomers
title_short Tau oligomers
title_sort tau oligomers
topic RC346-429
R5-920
RC321-571
RC435-571
Q1-390
Tau phosphorylation
neurodegenerative disease
propagation
Tauopathy
tau protein
thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
topic_facet RC346-429
R5-920
RC321-571
RC435-571
Q1-390
Tau phosphorylation
neurodegenerative disease
propagation
Tauopathy
tau protein
thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKJ Neurology and clinical neurophysiology
url 17770
work_keys_str_mv AT jesusavila tauoligomers
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