Therapeutic Implications of Circadian Rhythms
Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed...
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| フォーマット: | Online |
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Frontiers Media SA
2021
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| _version_ | 1869531141610930176 |
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| author | Erquan Zhang Guangrui Yang Han Wang |
| author_browse | Erquan Zhang Guangrui Yang Han Wang |
| author_facet | Erquan Zhang Guangrui Yang Han Wang |
| author_sort | Erquan Zhang |
| collection | Directory of Open Access Books |
| description | Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms |
| format | Online |
| id | doab-20.500.12854ir-60862 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-608622024-04-01T14:15:06Z Therapeutic Implications of Circadian Rhythms Erquan Zhang Guangrui Yang Han Wang RM1-950 Q1-390 Cardiovascular Diseases Central Nervous System Therapeutic implications Circadian Clocks Clinical relevance Circadian Rhythm Metabolism circadian disruption thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Circadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. Topics include, but are not limited to: • Circadian disruption caused diseases or disorders and related intervention • Temporal manifestation of diseases or disorders and therapeutic implications • The effects of circadian rhythms on drugs • The effects of drugs on circadian rhythms 2021-02-12T05:51:29Z 2021-02-12T05:51:29Z 2016-08-16 10:34:25 2015 book 19566 16648714 9782889196654 https://directory.doabooks.org/handle/20.500.12854/60862 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Therapeutic_Implications_of_Circadian_Rhythms/703#nogo http://journal.frontiersin.org/researchtopic/3098/therapeutic-implications-of-circadian-rhythms Frontiers Media SA 10.3389/978-2-88919-665-4 10.3389/978-2-88919-665-4 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889196654 96 open access |
| spellingShingle | RM1-950 Q1-390 Cardiovascular Diseases Central Nervous System Therapeutic implications Circadian Clocks Clinical relevance Circadian Rhythm Metabolism circadian disruption thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Erquan Zhang Guangrui Yang Han Wang Therapeutic Implications of Circadian Rhythms |
| title | Therapeutic Implications of Circadian Rhythms |
| title_full | Therapeutic Implications of Circadian Rhythms |
| title_fullStr | Therapeutic Implications of Circadian Rhythms |
| title_full_unstemmed | Therapeutic Implications of Circadian Rhythms |
| title_short | Therapeutic Implications of Circadian Rhythms |
| title_sort | therapeutic implications of circadian rhythms |
| topic | RM1-950 Q1-390 Cardiovascular Diseases Central Nervous System Therapeutic implications Circadian Clocks Clinical relevance Circadian Rhythm Metabolism circadian disruption thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RM1-950 Q1-390 Cardiovascular Diseases Central Nervous System Therapeutic implications Circadian Clocks Clinical relevance Circadian Rhythm Metabolism circadian disruption thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 19566 |
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