Thyroid hormone in brain and brain cells
Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormo...
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| প্রধান লেখক: | , , |
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| বিন্যাস: | Online |
| ভাষা: | ইংরেজি |
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Frontiers Media SA
2021
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | 18826 |
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| _version_ | 1869525500376907776 |
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| author | Juan Bernal Frederic Flamant Noriyuki Koibuchi |
| author_browse | Frederic Flamant Juan Bernal Noriyuki Koibuchi |
| author_facet | Juan Bernal Frederic Flamant Noriyuki Koibuchi |
| author_sort | Juan Bernal |
| collection | Directory of Open Access Books |
| description | Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation. |
| format | Online |
| id | doab-20.500.12854ir-60915 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media SA |
| publisherStr | Frontiers Media SA |
| record_format | ojs |
| spelling | doab-20.500.12854ir-609152022-01-31T09:35:14Z Thyroid hormone in brain and brain cells Juan Bernal Frederic Flamant Noriyuki Koibuchi RC648-665 R5-920 thyroid hormone neurodevelopment transporter nuclear receptor brain deiodinase Thyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation. 2021-02-12T05:55:03Z 2021-02-12T05:55:03Z 2016-04-07 11:22:02 2016 book 18826 16648714 9782889197026 https://directory.doabooks.org/handle/20.500.12854/60915 eng Frontiers Research Topics image/jpeg Attribution 4.0 International http://www.frontiersin.org/books/Thyroid_Hormone_in_Brain_and_Brain_Cells/771 http://journal.frontiersin.org/researchtopic/1929/thyroid-hormone-in-brain-and-brain-cells Frontiers Media SA 10.3389/978-2-88919-702-6 10.3389/978-2-88919-702-6 bf5ce210-e72e-4860-ba9b-c305640ff3ae 9782889197026 106 open access |
| spellingShingle | RC648-665 R5-920 thyroid hormone neurodevelopment transporter nuclear receptor brain deiodinase Juan Bernal Frederic Flamant Noriyuki Koibuchi Thyroid hormone in brain and brain cells |
| title | Thyroid hormone in brain and brain cells |
| title_full | Thyroid hormone in brain and brain cells |
| title_fullStr | Thyroid hormone in brain and brain cells |
| title_full_unstemmed | Thyroid hormone in brain and brain cells |
| title_short | Thyroid hormone in brain and brain cells |
| title_sort | thyroid hormone in brain and brain cells |
| topic | RC648-665 R5-920 thyroid hormone neurodevelopment transporter nuclear receptor brain deiodinase |
| topic_facet | RC648-665 R5-920 thyroid hormone neurodevelopment transporter nuclear receptor brain deiodinase |
| url | 18826 |
| work_keys_str_mv | AT juanbernal thyroidhormoneinbrainandbraincells AT fredericflamant thyroidhormoneinbrainandbraincells AT noriyukikoibuchi thyroidhormoneinbrainandbraincells |