Toxins in Drug Discovery and Pharmacology
Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are con...
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| Aineistotyyppi: | Online |
| Kieli: | englanti |
| Julkaistu: |
MDPI - Multidisciplinary Digital Publishing Institute
2021
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| Aiheet: | |
| Linkit: | 26653 |
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| _version_ | 1869517622655057920 |
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| author | Steve Peigneur (Ed.) |
| author_browse | Steve Peigneur (Ed.) |
| author_facet | Steve Peigneur (Ed.) |
| author_sort | Steve Peigneur (Ed.) |
| collection | Directory of Open Access Books |
| description | Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology for their own biological purposes by producing venoms that contain a structural and functional diversity of neurotoxins. These neurotoxins appear to be highly selective ligands for a wide range of ion channels and receptors. Therefore, they represent interesting lead compounds for the development of analgesics, anti-cancer drugs, drugs for neurological disorders such as multiple sclerosis, Parkinson' s disease, Alzheimer' s disease, and other therapeutics. This Special Issue of Toxins aims to provide a comprehensive look at toxins and toxin-inspired leads and will focus on the mechanisms of action, structure–function relationships, and evolution of pharmacologically interesting venom components, including the most recent developments related to the emergence of venoms as an underutilized source of highly evolved bioactive peptides with clinical potential. |
| format | Online |
| id | doab-20.500.12854ir-61071 |
| institution | Directory of Open Access Books |
| language | eng |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | MDPI - Multidisciplinary Digital Publishing Institute |
| publisherStr | MDPI - Multidisciplinary Digital Publishing Institute |
| record_format | ojs |
| spelling | doab-20.500.12854ir-610712024-04-01T14:14:51Z Toxins in Drug Discovery and Pharmacology Steve Peigneur (Ed.) RA1190-1270 calcium channels acetylcholine receptors peptides botulinum toxins TRP channels spider venom peptides sodium channels opiate receptors Antibiotics cone snail venom potassium channels chloride ion channels ASIC channels NMDA receptor antimicrobial peptides thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Venoms from marine and terrestrial animals (cone snails, scorpions, spiders, snakes, centipedes, cnidarian, etc.) can be seen as untapped cocktails of biologically active compounds that are being increasingly recognized as a new emerging source of peptide-based therapeutics. Venomous animals are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharmacology for their own biological purposes by producing venoms that contain a structural and functional diversity of neurotoxins. These neurotoxins appear to be highly selective ligands for a wide range of ion channels and receptors. Therefore, they represent interesting lead compounds for the development of analgesics, anti-cancer drugs, drugs for neurological disorders such as multiple sclerosis, Parkinson' s disease, Alzheimer' s disease, and other therapeutics. This Special Issue of Toxins aims to provide a comprehensive look at toxins and toxin-inspired leads and will focus on the mechanisms of action, structure–function relationships, and evolution of pharmacologically interesting venom components, including the most recent developments related to the emergence of venoms as an underutilized source of highly evolved bioactive peptides with clinical potential. 2021-02-12T06:11:42Z 2021-02-12T06:11:42Z 2018-05-04 11:37:49 2018 book 26653 9783038428619 9783038428626 https://directory.doabooks.org/handle/20.500.12854/61071 eng image/png Attribution-NonCommercial-NoDerivatives 4.0 International http://www.mdpi.com/books/pdfview/book/608 http://www.mdpi.com/books/pdfview/book/608 MDPI - Multidisciplinary Digital Publishing Institute 46cabcaa-dd94-4bfe-87b4-55023c1b36d0 9783038428619 9783038428626 XII, 304 open access |
| spellingShingle | RA1190-1270 calcium channels acetylcholine receptors peptides botulinum toxins TRP channels spider venom peptides sodium channels opiate receptors Antibiotics cone snail venom potassium channels chloride ion channels ASIC channels NMDA receptor antimicrobial peptides thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology Steve Peigneur (Ed.) Toxins in Drug Discovery and Pharmacology |
| title | Toxins in Drug Discovery and Pharmacology |
| title_full | Toxins in Drug Discovery and Pharmacology |
| title_fullStr | Toxins in Drug Discovery and Pharmacology |
| title_full_unstemmed | Toxins in Drug Discovery and Pharmacology |
| title_short | Toxins in Drug Discovery and Pharmacology |
| title_sort | toxins in drug discovery and pharmacology |
| topic | RA1190-1270 calcium channels acetylcholine receptors peptides botulinum toxins TRP channels spider venom peptides sodium channels opiate receptors Antibiotics cone snail venom potassium channels chloride ion channels ASIC channels NMDA receptor antimicrobial peptides thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| topic_facet | RA1190-1270 calcium channels acetylcholine receptors peptides botulinum toxins TRP channels spider venom peptides sodium channels opiate receptors Antibiotics cone snail venom potassium channels chloride ion channels ASIC channels NMDA receptor antimicrobial peptides thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology |
| url | 26653 |
| work_keys_str_mv | AT stevepeigneured toxinsindrugdiscoveryandpharmacology |